Evaluation of the Immundolatory Effect of Oral Administration of Methanol Extract of Gongronema latifolium (Utazi) in Wistar Albino Rats:- Samuel, Victor P.
ABSTRACT
The aim of
the present study was to evaluate the immunomodulatory potential of methanolic
extract of Gongronema latifolium (utazi) on wistar albino rats. A total of
sixteen (16) Wistar albino rats were used for the study and divided into four
(4) groups of four (4) rats each. The normal control was administered normal
saline while the negative control was administered pyrogal lol in order to
suppress the immune system. The treated rats were administered 200 mg/kg body
weight and 400 mg/kg body weight of the plant extract and 2% pyrogallol to
represent the low and high doses respectively. These administrations lasted 21
days after which blood was drawn through ocular puncture and serum collected
for the assay. The immunomodulatory activity was evaluated on haematological
indices (packed cell volume, haemoglobin and total white blood cell count),
cytokine expressions (interleukine-2, interferon-1 and tumour necrosis factor),
haemaglutination titre (primary and secondary humoral antibody) and the delayed
type hypersensitivity (DTH). No significant (p>0.05) differences were
observed in the haematological indices. Significant (p<0.05) increase was
seen in the interferon-, while a non-significant (p<0.05) increase was
obtained in tumour necrosis factor- and interleukine-2. The primary and
secondary antibody titre showed significant (p<0.05) increases and the
delayed type hypersensitivity also indicated a significant (p<0.05)
increase. These comparisons were made against thenegative control. This study
suggests that the extract of G. latifolium possess immunostimulatory effect and
its implication is that it is good for consumption as it helps the immune
system fight against diseases.
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SAMUEL, S (2023). Evaluation of the Immundolatory Effect of Oral Administration of Methanol Extract of Gongronema latifolium (Utazi) in Wistar Albino Rats:- Samuel, Victor P.. Repository.mouau.edu.ng: Retrieved Nov 24, 2024, from https://repository.mouau.edu.ng/work/view/evaluation-of-the-immundolatory-effect-of-oral-administration-of-methanol-extract-of-gongronema-latifolium-utazi-in-wistar-albino-rats-samuel-victor-p-7-2
SAMUEL, SAMUEL. "Evaluation of the Immundolatory Effect of Oral Administration of Methanol Extract of Gongronema latifolium (Utazi) in Wistar Albino Rats:- Samuel, Victor P." Repository.mouau.edu.ng. Repository.mouau.edu.ng, 27 Nov. 2023, https://repository.mouau.edu.ng/work/view/evaluation-of-the-immundolatory-effect-of-oral-administration-of-methanol-extract-of-gongronema-latifolium-utazi-in-wistar-albino-rats-samuel-victor-p-7-2. Accessed 24 Nov. 2024.
SAMUEL, SAMUEL. "Evaluation of the Immundolatory Effect of Oral Administration of Methanol Extract of Gongronema latifolium (Utazi) in Wistar Albino Rats:- Samuel, Victor P.". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 27 Nov. 2023. Web. 24 Nov. 2024. < https://repository.mouau.edu.ng/work/view/evaluation-of-the-immundolatory-effect-of-oral-administration-of-methanol-extract-of-gongronema-latifolium-utazi-in-wistar-albino-rats-samuel-victor-p-7-2 >.
SAMUEL, SAMUEL. "Evaluation of the Immundolatory Effect of Oral Administration of Methanol Extract of Gongronema latifolium (Utazi) in Wistar Albino Rats:- Samuel, Victor P." Repository.mouau.edu.ng (2023). Accessed 24 Nov. 2024. https://repository.mouau.edu.ng/work/view/evaluation-of-the-immundolatory-effect-of-oral-administration-of-methanol-extract-of-gongronema-latifolium-utazi-in-wistar-albino-rats-samuel-victor-p-7-2