Isolation And Antibiotic Sensitivity Profile Of Salmonella Typhi Isolates From Stool Of Patients In Some Hospitals In Owerri Municipal.

ABSTRACT

Fifty (50) stool samples were collected from the patients (male and female) of two known hospitals (International Christian Hospital and St. David Hospital) in Owen municipal, to isolate and evaluate the antibiotic sensitivity profile of S. typhi in the patients population. The antibiotic sensitivity pattern was determined using disc diffusion method with Abtek brand of sensitivity disc. Of the 50 samples only 10(20%) produced significant growth and the antibiotic sensitivity testing was carried out on the 10 isolates. The antibiotic sensitivity testing revealed that (8) 0% of the isolates were sensitivity to nitrofurantoin (80%), gentamycin (50%), nalixidic acid (40%), streptornycin (40%), colistin (10%) and cotrimoxazole (10%). All the isolates were completely resistant to ampicillin and tetracycline. This work shows the importance of antibiotics testing before using any antibiotic for treatment of S. typhi infection. The antibiotic sensitivity pattern of the isolates revealed a high sensitivity to antibiotics (chloramphenicol,ampicillin,amocillin)not frequently used for the treatment of S.typhi infection and a high resistance to antibiotics commonly used.