Zinc Concentration In The Serum And Liver Homogenate Of Normal And Monosodium Glutamate Intoxicated Rats Co-Treated With Artemether-Lumenfantrine:- Chukwu Ebere M
ABSTRACT
Monosodium
glutamate (MSG) commonly known as Ajino moto, is the sodium salt ofthe
non-essential amino acid glutamic acid (Ewaka., 2007). It has a
flavourenhancing effect and for this reason it is added to foods.
Artemether-lumenfantrine is an Artemisinin derivatives that possess an
endoperoxide bridge in their structure which is crucial to its antimalarial
activity (Awofisayo et al.,2Q\Q). The endoperoxide bridge is very unstable in
the presence of heme iron and malaria parasites are rich in heme. This bridge
is broken down upon interaction with intraparasitic heme in the digestive
vacuole leading to the release of free radicals. These free radicals are toxic
to the parasite and damage specific intracellular targets possibly by
alkylation (Meshnick, 2002). Another suggested mode of action of artemisinins
is the inhibition of sarcoplasmicendoplasmic reticulum Ca2+-ATPase ortholog
SERCA known as PfATP6 (Eckstein-Ludwig et al., 2003, Valderramos et al., 2010).
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CHUKWU, M (2024). Zinc Concentration In The Serum And Liver Homogenate Of Normal And Monosodium Glutamate Intoxicated Rats Co-Treated With Artemether-Lumenfantrine:- Chukwu Ebere M. Repository.mouau.edu.ng: Retrieved Nov 21, 2024, from https://repository.mouau.edu.ng/work/view/zinc-concentration-in-the-serum-and-liver-homogenate-of-normal-and-monosodium-glutamate-intoxicated-rats-co-treated-with-artemether-lumenfantrine-chukwu-ebere-m-7-2
MERCY, CHUKWU. "Zinc Concentration In The Serum And Liver Homogenate Of Normal And Monosodium Glutamate Intoxicated Rats Co-Treated With Artemether-Lumenfantrine:- Chukwu Ebere M" Repository.mouau.edu.ng. Repository.mouau.edu.ng, 10 Oct. 2024, https://repository.mouau.edu.ng/work/view/zinc-concentration-in-the-serum-and-liver-homogenate-of-normal-and-monosodium-glutamate-intoxicated-rats-co-treated-with-artemether-lumenfantrine-chukwu-ebere-m-7-2. Accessed 21 Nov. 2024.
MERCY, CHUKWU. "Zinc Concentration In The Serum And Liver Homogenate Of Normal And Monosodium Glutamate Intoxicated Rats Co-Treated With Artemether-Lumenfantrine:- Chukwu Ebere M". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 10 Oct. 2024. Web. 21 Nov. 2024. < https://repository.mouau.edu.ng/work/view/zinc-concentration-in-the-serum-and-liver-homogenate-of-normal-and-monosodium-glutamate-intoxicated-rats-co-treated-with-artemether-lumenfantrine-chukwu-ebere-m-7-2 >.
MERCY, CHUKWU. "Zinc Concentration In The Serum And Liver Homogenate Of Normal And Monosodium Glutamate Intoxicated Rats Co-Treated With Artemether-Lumenfantrine:- Chukwu Ebere M" Repository.mouau.edu.ng (2024). Accessed 21 Nov. 2024. https://repository.mouau.edu.ng/work/view/zinc-concentration-in-the-serum-and-liver-homogenate-of-normal-and-monosodium-glutamate-intoxicated-rats-co-treated-with-artemether-lumenfantrine-chukwu-ebere-m-7-2