Synthesis, Characterization And Antibacterial Activities Of Phenylmethylidene-(1-3-THIAZOLE-2YLMETHYL) Sulfonyl Methylaniline Schiff Base and its Fe (III) Ni (II) and Mn (II) Complexes.

ANYANWU | 1 page (13970 words) | Theses
Chemistry | Co Authors: JUDITHMARY CHIDIMMA

 

ABSTRACT

Phenylmethylidene-(1-3-thiazole-2ylmethyl) sulfonylmethylaniline Schiff bases [PTSA] was prepared by a reaction between benzaldehyde and sulphathiazole. Fe(III), Mn(II) and Ni(II) complexes of PTSA were also synthesized, melting point and conductivity of the ligand and metal complexes were determined. The PTSA and Fe(III), Mn(II) and Ni(II) complexes were characterized by Ultraviolet/Visible, IR, HNMR and 13CNMR spectroscopy. Low conductivity value ranging from 10.5-17.2 Sm2.mol-1 indicated the non-electrolytic nature of the PTSA and Fe(III), Mn(II) and Ni(II) complexes. The melting point of the PTSA and its complexes ranges from 244 - 286 The PTSA behaved as a tridentate ligand towards Mn, Fe and Ni ion, it complexed at -NH group and two C=N group. It has the general formular of [M(PTSA)n] (where M = metal ion, n = number of moles of ligand). A trigonal geometry has been proposed for the metal complexes. PTSA and metal (II) complexes have been screened for their in vitro antibacterial activity against four bacterial strains staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi. It was observed that the complexes were more potent than PTSA against the bacterial strains used. In line with the findings, PTSA metal complexes of Fe(III), Mn(II) and Ni(II) may be used as metal based drugs in the treatment of bacterial infections caused by staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi

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APA

ANYANWU, A (2022). Synthesis, Characterization And Antibacterial Activities Of Phenylmethylidene-(1-3-THIAZOLE-2YLMETHYL) Sulfonyl Methylaniline Schiff Base and its Fe (III) Ni (II) and Mn (II) Complexes.. Repository.mouau.edu.ng: Retrieved Jan 26, 2023, from https://repository.mouau.edu.ng/work/view/synthesis-characterization-and-antibacterial-activities-of-phenylmethylidene-1-3-thiazole-2ylmethyl-sulfonyl-methylaniline-schiff-base-and-its-fe-iii-ni-ii-and-mn-ii-complexes-7-2

MLA 8th

ANYANWU, ANYANWU. "Synthesis, Characterization And Antibacterial Activities Of Phenylmethylidene-(1-3-THIAZOLE-2YLMETHYL) Sulfonyl Methylaniline Schiff Base and its Fe (III) Ni (II) and Mn (II) Complexes." Repository.mouau.edu.ng. Repository.mouau.edu.ng, 17 Oct. 2022, https://repository.mouau.edu.ng/work/view/synthesis-characterization-and-antibacterial-activities-of-phenylmethylidene-1-3-thiazole-2ylmethyl-sulfonyl-methylaniline-schiff-base-and-its-fe-iii-ni-ii-and-mn-ii-complexes-7-2. Accessed 26 Jan. 2023.

MLA7

ANYANWU, ANYANWU. "Synthesis, Characterization And Antibacterial Activities Of Phenylmethylidene-(1-3-THIAZOLE-2YLMETHYL) Sulfonyl Methylaniline Schiff Base and its Fe (III) Ni (II) and Mn (II) Complexes.". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 17 Oct. 2022. Web. 26 Jan. 2023. < https://repository.mouau.edu.ng/work/view/synthesis-characterization-and-antibacterial-activities-of-phenylmethylidene-1-3-thiazole-2ylmethyl-sulfonyl-methylaniline-schiff-base-and-its-fe-iii-ni-ii-and-mn-ii-complexes-7-2 >.

Chicago

ANYANWU, ANYANWU. "Synthesis, Characterization And Antibacterial Activities Of Phenylmethylidene-(1-3-THIAZOLE-2YLMETHYL) Sulfonyl Methylaniline Schiff Base and its Fe (III) Ni (II) and Mn (II) Complexes." Repository.mouau.edu.ng (2022). Accessed 26 Jan. 2023. https://repository.mouau.edu.ng/work/view/synthesis-characterization-and-antibacterial-activities-of-phenylmethylidene-1-3-thiazole-2ylmethyl-sulfonyl-methylaniline-schiff-base-and-its-fe-iii-ni-ii-and-mn-ii-complexes-7-2

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