Effect Of Ethanol Extract Of Gouania Longipetala On Selected Clinically- Important Enzymes Of Acetaminophen-Overdosed Albino Rats:- Ukoha, Goodness C.
ABSTRACT
The
albino rats were randomly divided into five groups each consisting offour
albino rats Group 1 rats were the normal control and were given feed and water
adlibitum for a period of 14 days. Hepatotoxicity was induced invivo in all the
rats ofGroups 2’ n 4 5 orally by administermg 1 -5g /kg body weight
ofparacetamol. Group 3, 4 and 5 were orally administered Gouania longipetela
200 mg/kg, 600mg/kg and lOOOmg/kg body weight respectively daily for a period
of 14 days. Group 2 rats were the negative control and they were not given the
extract. The result of this study shows that rats treated with Gouania
longipetela extract significantly (P<0.05) have reduced clinically important
liver enzymes Oral administratmn ofacetaminophen caused marked liver damage as
noted by the significant increased (P<0.05) m activities ofplasma AST, ALT
and ALP. Treatment with the extract showed effective hepatoprotection as
evidence in the decrease in the plasma levels ofliver biomarker enzymes.
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GOODNESS, C (2024). Effect Of Ethanol Extract Of Gouania Longipetala On Selected Clinically- Important Enzymes Of Acetaminophen-Overdosed Albino Rats:- Ukoha, Goodness C. . Repository.mouau.edu.ng: Retrieved Jul 27, 2024, from https://repository.mouau.edu.ng/work/view/effect-of-ethanol-extract-of-gouania-longipetala-on-selected-clinically-important-enzymes-of-acetaminophen-overdosed-albino-rats-ukoha-goodness-c-7-2
CHISOM, GOODNESS. "Effect Of Ethanol Extract Of Gouania Longipetala On Selected Clinically- Important Enzymes Of Acetaminophen-Overdosed Albino Rats:- Ukoha, Goodness C. " Repository.mouau.edu.ng. Repository.mouau.edu.ng, 26 Feb. 2024, https://repository.mouau.edu.ng/work/view/effect-of-ethanol-extract-of-gouania-longipetala-on-selected-clinically-important-enzymes-of-acetaminophen-overdosed-albino-rats-ukoha-goodness-c-7-2. Accessed 27 Jul. 2024.
CHISOM, GOODNESS. "Effect Of Ethanol Extract Of Gouania Longipetala On Selected Clinically- Important Enzymes Of Acetaminophen-Overdosed Albino Rats:- Ukoha, Goodness C. ". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 26 Feb. 2024. Web. 27 Jul. 2024. < https://repository.mouau.edu.ng/work/view/effect-of-ethanol-extract-of-gouania-longipetala-on-selected-clinically-important-enzymes-of-acetaminophen-overdosed-albino-rats-ukoha-goodness-c-7-2 >.
CHISOM, GOODNESS. "Effect Of Ethanol Extract Of Gouania Longipetala On Selected Clinically- Important Enzymes Of Acetaminophen-Overdosed Albino Rats:- Ukoha, Goodness C. " Repository.mouau.edu.ng (2024). Accessed 27 Jul. 2024. https://repository.mouau.edu.ng/work/view/effect-of-ethanol-extract-of-gouania-longipetala-on-selected-clinically-important-enzymes-of-acetaminophen-overdosed-albino-rats-ukoha-goodness-c-7-2