Body Weight Changes And Lipid Profile Values In Monosodium Glutamate Intoxicated Wister Rats Co-Treated With Different Solvents Extract Of Dacryodes Edulis:- Keziah Chinonyerem E
ABSTRACT
Dyslipidemia
which includes not only quantitative but also qualitative abnormalities of
lipoprotein plays a significant role in the proatherogenesis ofvascular
complications in diseases. Hypercholesterolemia is associated with serious health
risks, increased mortality. The aim ofthis study is to determine the body
weight changes and lipid profile values in monosodium glutamate intoxicated
wister rats co-treated with different solvents extract of Dacryodesedulis.To
achieve this, a total of 48 rats were shared into 8 groups of 6 animals each.
Group 1 received food and water while group 2 received 800mg/kg monosodium
glutamate. Group 3 was co-treated sylimarin while the other treatment groups
were treated with ethanol fraction, methanol fraction, ethylacetete fraction,
N-hexane fraction and aqueous fraction. The result of the lipid profile showed
significant (p<0.05) increase in the LDL, VLDL, Cholesterol and triglyceride
of the MSG group coupled with significant reduction in HDL. However, the
different fractions all showed significant (p<0.05) decrease of in LDL,
VLDL, cholesterol and triglyceride with concomitant significant (p<0.05)
increase in HDL concentration across the groups. The Nhexane notably exhibited
this trend the most thereby giving the possible initiative of having the most
anti-lipidemic activity of all the treatment fractions. There was also positive
weigh gain across all the groups with the MSG showing highest weigh gain after
the control group while the N-hexane fraction showed the lowest weight gain. In
conclusion, it could be said that different solvents extract of
Dacryodesedulisshowed antilipidemic activity with the N-hexane fraction showing
the most property.
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KEZIAH, E (2024). Body Weight Changes And Lipid Profile Values In Monosodium Glutamate Intoxicated Wister Rats Co-Treated With Different Solvents Extract Of Dacryodes Edulis:- Keziah Chinonyerem E. Repository.mouau.edu.ng: Retrieved Dec 22, 2024, from https://repository.mouau.edu.ng/work/view/body-weight-changes-and-lipid-profile-values-in-monosodium-glutamate-intoxicated-wister-rats-co-treated-with-different-solvents-extract-of-dacryodes-edulis-keziah-chinonyerem-e-7-2
EZINWA, KEZIAH. "Body Weight Changes And Lipid Profile Values In Monosodium Glutamate Intoxicated Wister Rats Co-Treated With Different Solvents Extract Of Dacryodes Edulis:- Keziah Chinonyerem E" Repository.mouau.edu.ng. Repository.mouau.edu.ng, 24 Oct. 2024, https://repository.mouau.edu.ng/work/view/body-weight-changes-and-lipid-profile-values-in-monosodium-glutamate-intoxicated-wister-rats-co-treated-with-different-solvents-extract-of-dacryodes-edulis-keziah-chinonyerem-e-7-2. Accessed 22 Dec. 2024.
EZINWA, KEZIAH. "Body Weight Changes And Lipid Profile Values In Monosodium Glutamate Intoxicated Wister Rats Co-Treated With Different Solvents Extract Of Dacryodes Edulis:- Keziah Chinonyerem E". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 24 Oct. 2024. Web. 22 Dec. 2024. < https://repository.mouau.edu.ng/work/view/body-weight-changes-and-lipid-profile-values-in-monosodium-glutamate-intoxicated-wister-rats-co-treated-with-different-solvents-extract-of-dacryodes-edulis-keziah-chinonyerem-e-7-2 >.
EZINWA, KEZIAH. "Body Weight Changes And Lipid Profile Values In Monosodium Glutamate Intoxicated Wister Rats Co-Treated With Different Solvents Extract Of Dacryodes Edulis:- Keziah Chinonyerem E" Repository.mouau.edu.ng (2024). Accessed 22 Dec. 2024. https://repository.mouau.edu.ng/work/view/body-weight-changes-and-lipid-profile-values-in-monosodium-glutamate-intoxicated-wister-rats-co-treated-with-different-solvents-extract-of-dacryodes-edulis-keziah-chinonyerem-e-7-2