The Effect Of Methanol Extract Of Mucuna Prurienspruriens (Velvet Bean) Leaves On Renal Function And Redox Status Of Alloxan Induced Diabetic Rat

ABSTRACT

The methanol extract of Mucuna prurienspruriens (Fabaceae) leaves was investigated for antidiabetic activity using alloxan-induced diabetic rats. The following parameters were clinically analyzed: catalase, malondialdehyde (MDA), superoxide dismutase (SOD), reduced glutathione (GSH), vitamin E, vitamin C, creatinine, glutathione peroxide (GPX), fasting blood sugar (FBS). Tire total of25 wistar Albino rats used were randomly assigned into 4 groups (A-D). Group A was not subjected into hepatocyte damage, but received only normal feed and water. Group B was given water, feed and were induced with diabetes but without treatment, Group C received both water, feed, induced with diabetes and were treated with standard drug, glibenclamide, Group D rats received water, feed, diabetes induced and treated with extract ofMucunaprurienspruriens at dose (50mg/kg and lOOmg/kg) body weight. The results of the catalase, MDA, presented showed a significant (P<0.05) increase in the untreated diabetic group B (negative control), and group treated with the standard drug, when compared with the normal control. The result of GPx, GSH showed a significant (P<0.05) decrease in the untreated diabetic group (negative control), and groups treated with the standard drug. When compared with the Normal control. Vitamin C, E and SOD showed no significant difference (P>0.05) in all the groups treated with 50mg/kg ofthe Mucuna prurienspruriens extract when compared with the untreated diabetic group. The plant extract had a positive effect on the renal function ofthe rat.