Glutathione Peroxidase Activity, Malondialdehyde And Total Protein Concentration In The Brain Homogenate Of Normal And Monosodium Glutamate Intoxicated Rats Co-Treated With Arthemeter Lumefantrine :- Okereke, Goodness C

ABSTRACT vi Food additives have been used widely for promotion of food safety, flavoring and coloring. This study was aimed at investigating glutathione peroxidase activity, malondidehyde and total protein concentration of normal and monosodium glutamate (MSG) intoxicated rats co treated with artemether lumefantrine (ACT). Thirty rats were randomly shared into six groups (control, ACT therapeutic, ACT High, MSG, MSG +ACT therapeutic and MSG + ACT high) with five rats in each group and treated for 7 days. Results showed that the glutathione peroxidase activity of ACT treated rats was increased significantly (P<0.05) and the MDA level and total protein level of MSG treated rats were significantly (P<0.05) increased, when compared to the control group rats. Also, there was a significant (P<0.05) increase in the total protein concentration of MSG + ACT high treated rats compared to MSG treated group. It was concluded that artemether lumefantrine has no adverse effect on the oxidant concentration in the brain at a short period of time, and it also demonstrates a slight mitigating ability in oxidative stress formation when cotreated with MSG.