Evaluation Of Liver Function Enzymes Of Alchornea Cordifolia Methanol-Methylene Chloride Extract On CCL- Induced Hepatotoxicity In Wister Albino Rats:- Emelogu Precious C.

ABSTRACT

 Liver function enzymes were evaluated using methanol/methylene chloride extract of Alchornea cordifolia in CCL$ induced hepatotoxicity in wister albino rats. Six (6) groups of 4 rats each: were treated with I 00mg/kg, 200mg/kg, 400mg/kg methanol/methylene chloride extract of Alchornea cordifolia with normal control, vehicle control and negative control respectively. However the result indicates that ALT activities in liver were significantly (p<0.05) highest in negative control rats when compared with nonnal control and other experimental groups, rat treated with methanol/methylene chloride extract of Alchorea cordifolia compared well (p>0.05) with control value in their liver ALT activities. The liver AST activities were significantly (p<0.05) raised in negative control rats when compared with normal control and other experimental group. The ALP activities in liver were significantly (p<0.05) highest respectively in negative control rats when compared with nonnal control and other experimental group. The liver total proteins were significantly (p<0.05) highest in the control rats and lowest in the negative control than all other experimental group. Methanol/methylene chloride extract of Alchornea cordifolia indicated the ability to ameliorate the adverse effects of CCL.i-induced Liver damage and could therefore, be recommended as an effective natural product for the management of liver disease.