Effects Of Hydro-Ethanolic Extract Of Amaranthus Hybrids Leaves On Some Antioxidant Enzymes In Tiboacet Amide Intoxicated Rats

ABSTRACT

The study was carried out to evaluate the effect of hydro-alcoholic extract of Amaranthus hybridus leaves on antioxidant enzymes of thioacetamide intoxicated rats. Thirty-six rats used for this study were randomly distributed into six groups. The normal control received normal feed and water, the positive control received the thioacetamide induced water and silymarin ( conventional drug), negative control received only thioacetamide, the test groups were treated with 100mg/kg, 200mg/kg, 400mg/kg of Amaranthus hybridus leaves extract respectively. The administration of the thioacetamide, drug and Amaranthus hybridus leaves extract were orally at single doses per day for nine weeks. Result showed that the test groups significantly (p < 0.05) increased the levels of SOD, CAT, and GPx activities when compared to the negative control. The results suggest that thioacetamide actually induced hepatotoxicity. While Amaranthus hybridus leaves extract appreciably increased the levels of antioxidants in hepatic tissues.