Effect Of Oral Administration Of Aqueous Root Extract Of Sphenocentrum Jollyanum On Some Liver Enzymes In Diabetes Induced Wistar Albino Rats. :- Ugwu, Salome, T

ABSTRACT ix was normal This study was carried out to assess the anti-diabetic properties of aqueous root extract of Sphenocentrum jollyanum on AST, ALT, ALP and GGT in Wistar albino rats. Twenty(20) male rats with body weight 130 to 200g were divided into five (5) experimental groups with equal numbers. Group A control, group B was positive control (std drug), group C was negative control (diabetes untreated) group D was treated with low dose 200mg/kg ofthe extract, group E was treated with high dose 400mg/kg of the root extract of Sphenocentrum jollyanum respectively and was orally administered for fourteen(14) days. At the end of the experiment the animals were sacrified. Blood samples were collected for the determination of AST,ALT ALP and GGT. The result of the AST activity shows a significant (p<0.05) decrease at 200mg/kg and 400mg/kg compared to negative control. Also, the result ofthe ALT shows a significant (p<0.05) decrease at 200mg/kg and 400mg/kg compared to negative control. The result ofthe ALP activity shows a significant (p<0.05) decrease at 200mg/kg and 400mg/kg compared to negative control. Whereas the GGT activity shows a significant (p<0.05) increase at 200mg/kg and 400mg/kg compared to negative control. There was also a significant (p<0.05) dose dependent decrease in blood sugar level ofthe rats administered (aqueous root extract) when compared with the negative (diabetic) control. The oral administration of aqueous root extract of Sphenocentrum jollyanum was effective in reducing blood glucose concentration of diabetic rats. Equally, the aqueous root extract ofSphenocentrumjollyanum has hepatoprotective potential and ameliorated the hepatic assault induced by alloxan.