Effect Of Methanolic Leaf Extract Of Leea Guineensis On Liver Enzymes And Lipid Profile In Carbontetrachloride (Ccl4) Induced Hepatotoxicity In Wistar Albino Rats.:- Ochulo Florence Nnenna E.

ABSTRACT Plants used for traditional medicine contain a wide range of substances which can be used to treat various infectious disease. Leeci guineensis is a genius of plants found in Northern and Eastern Austria, New guinea, South Asia and parts of Africa. Tire plant belong to the family Leeacea which has significant traditional usuage as medicine and is also known to biosynthesize phytochemicals such as flavonoids, saponins, alkaloids, polyuronoids, tannins, glycosides. It also contain carbohydrate and starch. This study investigated the effect of methanolic leaf extract of Leea guineensis on liver enzymes and lipid profile in carbontetra chloride (CC14) induced hepatotoxicity in albino wistar rats. Twenty four female albino wistar rats were used for this study, they were randomly grouped into six groups (A, B, C, D, E, F) with four rats in each group. Groups A-E were induced with carbontetrachloride while group F served as normal control and received no treatment while groups A,B,C were dosed with the extract (800,400,200 mg/kg respectively),group D received 10 mg/kg of silymarine. Group E served as the negative control and received 5 ml/kg of distilled water.. Tire blood samples were analyzed for biochemical markers of hepatic toxicity. The biochemical parameters in serum like alkaline phosphatase (ALP), aspartate transaminase (AST) and alanine transaminase (ALT) were significantly increased in treated groups compared to the control. Tire oral administration of different doses of methanolic extract of leea guineensis significant aggravates hepatotoxicity instead of offering hepatoprotection. The lipid profile levels were not significantly improved in treated groups compared to the control. This is inconclusive because of the short duration of the work. In conclusion, the study proved that Leea guineensis does not exhibit hepatoprotective effect against hepatotoxicity and should not be used as a hepatoprotective agent in Nigeria ethnomedicine.