Effect Of Methanol Leaves Extract Of Acanthus Monthanus On Some Immunological Parameters (Creactive Proteins, Interleukin-10 And Cd4+) In Wistar Rats:- Abonyi Ezekiel E

ABSTRACT 9 I The immune system is responsible for the proper functioning of the body. The aim of this study is to evaluate the effect of methanol leaves extract of A. monthanus on some immunological parameters (c-reactive protein, interleukin10 and CD4+) in Wistar rats. A total of 12 Wistar rats were used for this study; they were fed Vital feed and water ad libitum and acclimatized for a period of one (1) weeks after which they were grouped into three (3) equal groups. Group 1 served as normal control while groups 2 and 3 were administered the standard drug and methanol leaves extract of A. monthanus, respectively. The administration lasted for a period of three (3) weeks after which they were sacrificed and blood drawn via cardiac puncture and the tests done using standard methods. Results of CRP show that the standard drug group showed an insignificant (p>0.05) difference when compared to the normal control; while the normal control when compared to the group treated with 400mg/kg of A. monthanus showed a significant (p<0.05) increase. Result ofIL-10 shows a nonsignificant (p>0.05) difference when the group administered the extract is compared with the normal control and a significant (p<0.05) increase when compared with the standard drug group; while the CD4+ results showed a nonsignificant (p>0.05) increase when compared with the standard drug group and a non-significant (p>0.05) difference when compared with the normal control. From these results, it has been observed that the methanol leaves extract of A. monthanus, possesses some immunostimulatory properties.