Antinutrient In Bitter Leaf(Vernonia Amygdalina) Stem And Effect Of The Extract On Serum Lipid Profile In Normal And Monosodium Glutamate-Intoxicated Rats.:- Ibe Chika E

ABSTRACT x Vernonia amygdalina stem as food waste was assessed for antinutrient which include tannins ,phytate and trypsin inhibitor. The extract was administered to normal and monosodium glutamate- intoxicated rats. Using twenty(20) adult male wister rats with body weight ranging from 100-160g. The rats were randomly assigned into five groups viz the Control, the received only MSG group, the received only Extract group, MSG+Extract(200mg/kg) and MSG+Extract(400mg/kg). The exposure was daily for two weeks. On day fifteenth, the rats were sacrificed and the serum were used to evaluate lipid profile viz Total cholesterol, triacylglycerol, high density lipoprotein and low density lipoprotein. From the result there were significant (P<0.05)reduction in the level of total cholesterol and triacylglycerol of the extract group and a significant (P<0.05) increase in high density lipoprotein when compared to normal control. In the MSG received group only there was a significant (P<0.05) increase in the level of total cholesterol, triacylglycerol and low density lipoprotein and a marked reduction (P>0.05) high density lipoprotein. Thus vernonia amygdalina stem could significantly reduce MSG-induced hyperlipidemia in rats due to the antinutrient composition as recorded in the study