Antibacterial Activities Of Aqueous And Methanol Extracts Of Garcina Kola Leaf Extracts (Akilu) Against Some Bacterial Pathogens:- Okwuru, Bridget C.

ABSTRACT

Garcinia kola leaf (Akilu) exhibited antimicrobial activity against both the gram positive and gram negative test-organisms at 500ug/m and 250mg/m for methanolic extract except for P. aeruginosa (ATCC27854) which have no inhibition at 250ug/ml. Aqueous extracts of Garcinia kola leaf had strong inhibition against Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922) and Salmonella typhi at 500mg/ml. Partial – no inhibition was observed in lower concentrations at 62.5ug/ml and 31.2ug/ml. The extracts had MIC values ranging from 250mg/ml – 7.81mg/ml. MBC values ranges from 250mg/ml – 125mg/ml. There was no spectrum activity at methanolic extract and aqueous extracts of Garcinia kola leaf at the values of MIC at 250ug/ml. Strong inhibition was observed at MIC values at 250mg/ml. Antimicrobial activity was not observed for aqueous and methanol extracts of Garcinia kola leaf at 62.5ug/ml, 31.2ug/ml, 15.6ug/ml and 7.81ug/ml. The phytochemical screening showed that the extract of Garcinia kola leaf are rich in alkaloid (1.8%), saponin (2.04%), flavonoid (0.68%) and terpenoid (0.85%) appears to be low in quantity.