’Thioacetamide induced toxicity and hepatoprotective effect of Hibiscus Sabdariffa hydroacohol extract on albino wistar rats:- Kanu Ezinne E.
ABSTRACT
The work is
aimed at investigating thioaceamide induced toxicity and hepatoprotective
effect of Hibiscus Sabdariffa hydroalcohol extract on wistar albino rats.
Twenty rats were randomly grouped into five with four rats per group. Group 1
which is the positive control and other groups was given commercial rat fed and
water. Thioacetamide was orally induced to group 2 which is the negative
control. The animals in group’ 3 to 5 received oral administration of the
extract at different doses. Group 3 received extract 200mg/kg, group 4 received
400mg/kg and group 5 received 600mg/kg. The result revealed a significant
increase in aspartate aminotransferase (AST), alanine aminotransferase (ALT),
and bilirubin (BIL), and a significant decrease in alkaline phoshpatase (ALP)
and total protein (TP) level of the rats group with thiopacetamide. The results
also indicated that Hibiscus Sabdariffa plant extract has varying effect on the
liver function indices but also reduces toxicity. Thus it can be said that
Hibiscus Sabdariffa has a proective effect on the liver.
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KANU, E (2024). ’Thioacetamide induced toxicity and hepatoprotective effect of Hibiscus Sabdariffa hydroacohol extract on albino wistar rats:- Kanu Ezinne E.. Repository.mouau.edu.ng: Retrieved May 19, 2024, from https://repository.mouau.edu.ng/work/view/thioacetamide-induced-toxicity-and-hepatoprotective-effect-of-hibiscus-sabdariffa-hydroacohol-extract-on-albino-wistar-rats-kanu-ezinne-e-7-2
E, KANU. "’Thioacetamide induced toxicity and hepatoprotective effect of Hibiscus Sabdariffa hydroacohol extract on albino wistar rats:- Kanu Ezinne E." Repository.mouau.edu.ng. Repository.mouau.edu.ng, 29 Feb. 2024, https://repository.mouau.edu.ng/work/view/thioacetamide-induced-toxicity-and-hepatoprotective-effect-of-hibiscus-sabdariffa-hydroacohol-extract-on-albino-wistar-rats-kanu-ezinne-e-7-2. Accessed 19 May. 2024.
E, KANU. "’Thioacetamide induced toxicity and hepatoprotective effect of Hibiscus Sabdariffa hydroacohol extract on albino wistar rats:- Kanu Ezinne E.". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 29 Feb. 2024. Web. 19 May. 2024. < https://repository.mouau.edu.ng/work/view/thioacetamide-induced-toxicity-and-hepatoprotective-effect-of-hibiscus-sabdariffa-hydroacohol-extract-on-albino-wistar-rats-kanu-ezinne-e-7-2 >.
E, KANU. "’Thioacetamide induced toxicity and hepatoprotective effect of Hibiscus Sabdariffa hydroacohol extract on albino wistar rats:- Kanu Ezinne E." Repository.mouau.edu.ng (2024). Accessed 19 May. 2024. https://repository.mouau.edu.ng/work/view/thioacetamide-induced-toxicity-and-hepatoprotective-effect-of-hibiscus-sabdariffa-hydroacohol-extract-on-albino-wistar-rats-kanu-ezinne-e-7-2