The Effect of Methanol Seed Extract of Water Melon on Serum Electrolyte Balance in Dihydrotestosterol-Estradiol Velerate Induced Benign Prostatic Hyperplasia in male Wister Rat:- Ukpabi samuel. O
ABSTRACT
The
acute, toxicity, phytochemical and effect methanol extract of Citrullus lanatus
on PSA level and serum electrolyte were investigated using standard methods.
The result of the phytochemical analysis of Citrullus lanatus showed high
levels of flavonoid, saponin and reducing sugar. The LD50 was gotten at
500mg/kgbwt. The relative heart, kidney, lungs weight showed no p>0.05
significant difference. There was significant p<0.05 in relative prostate
weight of disease control group when compared with other treated group when
compared with other treated group while the relative testes significantly
(p<0.05) decreased in disease control when compared with the normal and
other treatment groups. The result of PSA level showed significant (p<0.05)
increase in disease control when compared with other treatment groups. The
serum electrolyte result showed that the level of sodium increased (p<0.05)
significantly in disease relative to the normal control and groups treated with
crude extract of a Citrullus lanatus. There w'as no (p>0.05) significant
difference in chloride concentration between the treatment groups. The result
also showed significant (p<0.05) decrease in potassium in disease and
disease control w'hen compared with group treated with 400mg/kg but the level
of Bicarbonate also decreased (p<0.05) significantly in disease control when
compared with 200mg/kgbwt. The result show that Citrullus lanatus contain
phytochemical that have the ability to reduce PSA and prostate weight relief of
symptom of BPH, Thus The pharmacological efficacy of the extracts is believed
to be due to synergistic effect of several compounds such as Flavonoids,
Saponin, Oxalate
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UKPABI, O (2024). The Effect of Methanol Seed Extract of Water Melon on Serum Electrolyte Balance in Dihydrotestosterol-Estradiol Velerate Induced Benign Prostatic Hyperplasia in male Wister Rat:- Ukpabi samuel. O. Repository.mouau.edu.ng: Retrieved Jul 27, 2024, from https://repository.mouau.edu.ng/work/view/the-effect-of-methanol-seed-extract-of-water-melon-on-serum-electrolyte-balance-in-dihydrotestosterol-estradiol-velerate-induced-benign-prostatic-hyperplasia-in-male-wister-rat-ukpabi-samuel-o-7-2
ONYEKACHI, UKPABI. "The Effect of Methanol Seed Extract of Water Melon on Serum Electrolyte Balance in Dihydrotestosterol-Estradiol Velerate Induced Benign Prostatic Hyperplasia in male Wister Rat:- Ukpabi samuel. O" Repository.mouau.edu.ng. Repository.mouau.edu.ng, 17 May. 2024, https://repository.mouau.edu.ng/work/view/the-effect-of-methanol-seed-extract-of-water-melon-on-serum-electrolyte-balance-in-dihydrotestosterol-estradiol-velerate-induced-benign-prostatic-hyperplasia-in-male-wister-rat-ukpabi-samuel-o-7-2. Accessed 27 Jul. 2024.
ONYEKACHI, UKPABI. "The Effect of Methanol Seed Extract of Water Melon on Serum Electrolyte Balance in Dihydrotestosterol-Estradiol Velerate Induced Benign Prostatic Hyperplasia in male Wister Rat:- Ukpabi samuel. O". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 17 May. 2024. Web. 27 Jul. 2024. < https://repository.mouau.edu.ng/work/view/the-effect-of-methanol-seed-extract-of-water-melon-on-serum-electrolyte-balance-in-dihydrotestosterol-estradiol-velerate-induced-benign-prostatic-hyperplasia-in-male-wister-rat-ukpabi-samuel-o-7-2 >.
ONYEKACHI, UKPABI. "The Effect of Methanol Seed Extract of Water Melon on Serum Electrolyte Balance in Dihydrotestosterol-Estradiol Velerate Induced Benign Prostatic Hyperplasia in male Wister Rat:- Ukpabi samuel. O" Repository.mouau.edu.ng (2024). Accessed 27 Jul. 2024. https://repository.mouau.edu.ng/work/view/the-effect-of-methanol-seed-extract-of-water-melon-on-serum-electrolyte-balance-in-dihydrotestosterol-estradiol-velerate-induced-benign-prostatic-hyperplasia-in-male-wister-rat-ukpabi-samuel-o-7-2