“The Effect of Methanol of Malay Apple Leaf (Syzygium malaccense) on Prostate Specific Antigen and Lipid Profile Parameters in Dihydrotestosterone - Estradiol Valarate Induced Benign Prostate Hyperplasia in Male Wistar Rat:- Anaelechukwu Chinyere B
ABSTRACT
This study
showed the effect of methanol extract of Malay apple leaf on PSA and lipid
profile parameters in dihydrotestosterone - estradiol valarate induced Benign
Prostate Hyperplasia in male Wister rats. Thirty (30) male Wistar rats aged
between 10 - 12 weeks, divided into five groups of 6 rats each were used in
this study. The lethal dose (LD50) is the concentration at which half of the
population dies was also determined. The lethal dose (LD50) of Syzygium
malaccense was found to be 5000mg/Kgbwt. Benign Prostate Hyperplasia was induced
by subcutaneous injection of 9mg/kg dihydrotestosterone (DHT) and 0.9mg/kg
estradiol valerate dissolved in olive oil every other day for 28 days. The
groups received different treatments, group 1- normal control, group 2 -disease
control, group 3- drug control, group 4 - lOOmg Malay apple leaf extract, and
group 5 -200mg Malay apple leaf extract. Biochemical parameters were assayed
using standard procedures. Result showed no significant difference (P >
0.05) between relative prostate weight of group 3 (Drug control) and group 5
(Rats administered with 200mg/kg bwt of extract). No significant difference was
observed in group 4 rat when compared to normal control rats. The relative
prostate weight of group 2 rats increased significantly (P < 0.05) compared
to all other groups. There were no significant difference (P > 0.05) in the
relative heart, liver and kidney. Serum prostate specific antigen increased
significantly in group 2, 4 and 5 compared to group 1 and 3. Cholesterol level
decreased significantly (P< 0.05) in group 5 (2.29mg/dl ± 0.22mg/dl) while
HDL - cholesterol increased (1.75mg/dl + 0.13mg/dl) relative to group 3
(1.85mg/dl + 0.05mg/dl). In group 2 cholesterol and LDL - cholesterol increased
significantly (P > 0.05) (7.04mg/dl ± 0.12mg/dl and 4.73mg/dl + 0.16mg/dl
while HDL - cholesterol decreased significantly in (P < 0.05) (0.29mg/dl ±
0.05mg/dl). This finding suggests that Malay apple leaf contain bioactive
agents that may be useful in the management of Benign Prostate Hyperplasia and
its complications, and can be of pharmacological importance in the management
ofBenign Prostate Hyperplasia.
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ANAELECHUKWU, B (2024). “The Effect of Methanol of Malay Apple Leaf (Syzygium malaccense) on Prostate Specific Antigen and Lipid Profile Parameters in Dihydrotestosterone - Estradiol Valarate Induced Benign Prostate Hyperplasia in Male Wistar Rat:- Anaelechukwu Chinyere B . Repository.mouau.edu.ng: Retrieved Nov 24, 2024, from https://repository.mouau.edu.ng/work/view/the-effect-of-methanol-of-malay-apple-leaf-syzygium-malaccense-on-prostate-specific-antigen-and-lipid-profile-parameters-in-dihydrotestosterone-estradiol-valarate-induced-benign-prostate-hyperplasia-in-male-wistar-rat-anaelechukwu-chinyere-b-7-2
B, ANAELECHUKWU. "“The Effect of Methanol of Malay Apple Leaf (Syzygium malaccense) on Prostate Specific Antigen and Lipid Profile Parameters in Dihydrotestosterone - Estradiol Valarate Induced Benign Prostate Hyperplasia in Male Wistar Rat:- Anaelechukwu Chinyere B " Repository.mouau.edu.ng. Repository.mouau.edu.ng, 04 Mar. 2024, https://repository.mouau.edu.ng/work/view/the-effect-of-methanol-of-malay-apple-leaf-syzygium-malaccense-on-prostate-specific-antigen-and-lipid-profile-parameters-in-dihydrotestosterone-estradiol-valarate-induced-benign-prostate-hyperplasia-in-male-wistar-rat-anaelechukwu-chinyere-b-7-2. Accessed 24 Nov. 2024.
B, ANAELECHUKWU. "“The Effect of Methanol of Malay Apple Leaf (Syzygium malaccense) on Prostate Specific Antigen and Lipid Profile Parameters in Dihydrotestosterone - Estradiol Valarate Induced Benign Prostate Hyperplasia in Male Wistar Rat:- Anaelechukwu Chinyere B ". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 04 Mar. 2024. Web. 24 Nov. 2024. < https://repository.mouau.edu.ng/work/view/the-effect-of-methanol-of-malay-apple-leaf-syzygium-malaccense-on-prostate-specific-antigen-and-lipid-profile-parameters-in-dihydrotestosterone-estradiol-valarate-induced-benign-prostate-hyperplasia-in-male-wistar-rat-anaelechukwu-chinyere-b-7-2 >.
B, ANAELECHUKWU. "“The Effect of Methanol of Malay Apple Leaf (Syzygium malaccense) on Prostate Specific Antigen and Lipid Profile Parameters in Dihydrotestosterone - Estradiol Valarate Induced Benign Prostate Hyperplasia in Male Wistar Rat:- Anaelechukwu Chinyere B " Repository.mouau.edu.ng (2024). Accessed 24 Nov. 2024. https://repository.mouau.edu.ng/work/view/the-effect-of-methanol-of-malay-apple-leaf-syzygium-malaccense-on-prostate-specific-antigen-and-lipid-profile-parameters-in-dihydrotestosterone-estradiol-valarate-induced-benign-prostate-hyperplasia-in-male-wistar-rat-anaelechukwu-chinyere-b-7-2