“the effect of methanol extract of annona muricata leaf on hematological parameters in dihydrotestosterone estradiol varelate induced benign prostatic hyperplasia (bph) in male wistar rat
ABSTRACT
The
effect of oral administration of methanol extract of Annona muricata leaf on
hematological parameters, body weight and relative organ weight was studied in
Benign prostatic hyperplasia (BPH) induced male albino rats. Phytochemical nd
acute toxicity study was conducted on the leaf of Annona muricata using
standard methods. Thirty rats were divided into five experimental groups of six
rats each; group 1- normal control, group 2- disease control (BPH-group), group
3- standard drugs control (finasteride-group), group 4 . and 5 (200 and
400mg/kg ofAnnona muricata extract respectively/ The normal control was not
induced with BPH but was given olive oil administered orally daily and
subcutaneous injection of olive oil was administered daily for 28 days. The
disease control group was induced dihydrotestosterone estradiol varelate daily
for 28days. The standard control group was given finasteride 5mg/70kg
administered orally daily. The 200mg/kg and 400mg/kg of methanol extract
ofAnnona muricata leafwas given to dihydrotestosterone estradiol varelate
induced rats orally daily. Results of the phytochemical studies showed high
levels of flavonoids (5.6200±0.01mg/100g), followed by saponins(4.8350±0.02mg/100g)and
reducing sugar (2.200±0.02 mg/lOOg). Terpene (1.350±0.007 mg/lOOg) has the
lowest concentration. The result also showed that PSA, lieutnizing hormone,
testosterone. DHT and estradiol decreased significantly (p<0.05) in groups treated
with different doses of extract. There was a significant increase (p<0.05)
in RBC of all experimental groups when compared with the control. This study
reveals important phytochemical constituent which shows that Annona muricata
may have beneficial effect in preventing or suppressing the development of BPH
and useful in treatment and management.
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OPURUWA, C (2023). “the effect of methanol extract of annona muricata leaf on hematological parameters in dihydrotestosterone estradiol varelate induced benign prostatic hyperplasia (bph) in male wistar rat. Repository.mouau.edu.ng: Retrieved Nov 25, 2024, from https://repository.mouau.edu.ng/work/view/the-effect-of-methanol-extract-of-annona-muricata-leaf-on-hematological-parameters-in-dihydrotestosterone-estradiol-varelate-induced-benign-prostatic-hyperplasia-bph-in-male-wistar-rat-7-2
CHINOMSO, OPURUWA. "“the effect of methanol extract of annona muricata leaf on hematological parameters in dihydrotestosterone estradiol varelate induced benign prostatic hyperplasia (bph) in male wistar rat" Repository.mouau.edu.ng. Repository.mouau.edu.ng, 12 Oct. 2023, https://repository.mouau.edu.ng/work/view/the-effect-of-methanol-extract-of-annona-muricata-leaf-on-hematological-parameters-in-dihydrotestosterone-estradiol-varelate-induced-benign-prostatic-hyperplasia-bph-in-male-wistar-rat-7-2. Accessed 25 Nov. 2024.
CHINOMSO, OPURUWA. "“the effect of methanol extract of annona muricata leaf on hematological parameters in dihydrotestosterone estradiol varelate induced benign prostatic hyperplasia (bph) in male wistar rat". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 12 Oct. 2023. Web. 25 Nov. 2024. < https://repository.mouau.edu.ng/work/view/the-effect-of-methanol-extract-of-annona-muricata-leaf-on-hematological-parameters-in-dihydrotestosterone-estradiol-varelate-induced-benign-prostatic-hyperplasia-bph-in-male-wistar-rat-7-2 >.
CHINOMSO, OPURUWA. "“the effect of methanol extract of annona muricata leaf on hematological parameters in dihydrotestosterone estradiol varelate induced benign prostatic hyperplasia (bph) in male wistar rat" Repository.mouau.edu.ng (2023). Accessed 25 Nov. 2024. https://repository.mouau.edu.ng/work/view/the-effect-of-methanol-extract-of-annona-muricata-leaf-on-hematological-parameters-in-dihydrotestosterone-estradiol-varelate-induced-benign-prostatic-hyperplasia-bph-in-male-wistar-rat-7-2