Phytochemical Content And Analgesic Activity Of Ethanol Extract Of Hibiscus Sabdariffa In Experimental Animal Model
ABSTRACT
This research work evaluates the phytochemical contents and analgesic properties of ethanol extract of Hibiscus sabdarffa. Fresh leaves of JI. Sabclari/fa were obtained, dried and milled. The samples were then analyzed l'or phytochernical composition using standard methods. The result shows the presence of flavonoids (28.66 %) and tannins (30.43 %) as the highest phytochemicals while others are alkaloids (20.74 %), phenols (18.93 %). cardiac glycosides (5.70 %) and saponins (15.60 %). The analgesic property was done using 20 female wistar albino rats weighing 80-120 g and grouped into 5 different groups (n=4). The rats were obtained from the Verterinary Department, University of Nigeria, Nsukka. Group one served as control and received only feed and water ad libitum, group 2: received morphine, intraperitoneally and Group 3, 4, and 5 received 1-libiscus sabdarifJh ethanol leaf extract (250, 500, 750 mg/kg) orally, respectively. The result showed thai. Bpercentage inhibition of writhing was significantly (p<O.OS) at 750 mg/kg bw (55.6 %) and compares competitively with morphine (50 %). Analgesic properties of Ii. Sabdar,fja was highest at 750 mg/kg bw and was significantly (p<O.OS) lower when compared with morphine. Therefore, these results shov that I-I. Sabdarijja can be used as an analgesic when consumed in a high concentration.
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IGBO, . (2021). Phytochemical Content And Analgesic Activity Of Ethanol Extract Of Hibiscus Sabdariffa In Experimental Animal Model. Repository.mouau.edu.ng: Retrieved Nov 23, 2024, from https://repository.mouau.edu.ng/work/view/phytochemical-content-and-analgesic-activity-of-ethanol-extract-of-hibiscus-sabdariffa-in-experimental-animal-model-7-2
.N., IGBO. "Phytochemical Content And Analgesic Activity Of Ethanol Extract Of Hibiscus Sabdariffa In Experimental Animal Model" Repository.mouau.edu.ng. Repository.mouau.edu.ng, 16 Jun. 2021, https://repository.mouau.edu.ng/work/view/phytochemical-content-and-analgesic-activity-of-ethanol-extract-of-hibiscus-sabdariffa-in-experimental-animal-model-7-2. Accessed 23 Nov. 2024.
.N., IGBO. "Phytochemical Content And Analgesic Activity Of Ethanol Extract Of Hibiscus Sabdariffa In Experimental Animal Model". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 16 Jun. 2021. Web. 23 Nov. 2024. < https://repository.mouau.edu.ng/work/view/phytochemical-content-and-analgesic-activity-of-ethanol-extract-of-hibiscus-sabdariffa-in-experimental-animal-model-7-2 >.
.N., IGBO. "Phytochemical Content And Analgesic Activity Of Ethanol Extract Of Hibiscus Sabdariffa In Experimental Animal Model" Repository.mouau.edu.ng (2021). Accessed 23 Nov. 2024. https://repository.mouau.edu.ng/work/view/phytochemical-content-and-analgesic-activity-of-ethanol-extract-of-hibiscus-sabdariffa-in-experimental-animal-model-7-2