Nephroprotective Potentials Of Methanol Extract Of Dennettiatripetala (Pepper Fruit) Fresh Leaves On Male Albino Rats:- Ndubueze, John-paul E.
ABSTRACT
This
study aimed at determining some kidney function indices in albino rats
administered methanol leave extract of Dennetiia tripetala. Twenty healthy male
albino rats weighing between 180- 240g were divided into four groups of five
rats each were used in this study. Group 1 was the control group, group 2
received an oral dose of 100 mg/kg, methanol leave extract of Dennettia
tripetala daily, group 3 received an oral dose of 200 mg/kg methanol leave
extract of Dennetiia tripetala daily while group 4 received an oral dose of 400
mg/kg ethanol leave extract of Dennettia tripetala daily. After 21 days of
administration the rats were sacrificed blood sample were collected through
ocular puncture to assay the biochemical parameters. The result of creatinine
(mol/L) showed a significant increase (p>0.05) when compared to the control
while urea (mol/L) showed significant decrease (p<0.05) when compared to the
control. In conclusion the result of this study has shown that administration
of methanol leave extract of Dennettia tripetala at dose over lOOmg/kg body
weight for a long period oftime may induce toxicity to the kidney which may
hamper renal dysfunction.
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EKENE, J (2024). Nephroprotective Potentials Of Methanol Extract Of Dennettiatripetala (Pepper Fruit) Fresh Leaves On Male Albino Rats:- Ndubueze, John-paul E.. Repository.mouau.edu.ng: Retrieved Dec 26, 2024, from https://repository.mouau.edu.ng/work/view/nephroprotective-potentials-of-methanol-extract-of-dennettiatripetala-pepper-fruit-fresh-leaves-on-male-albino-rats-ndubueze-john-paul-e-7-2
JOHN-PAUL, EKENE. "Nephroprotective Potentials Of Methanol Extract Of Dennettiatripetala (Pepper Fruit) Fresh Leaves On Male Albino Rats:- Ndubueze, John-paul E." Repository.mouau.edu.ng. Repository.mouau.edu.ng, 14 Oct. 2024, https://repository.mouau.edu.ng/work/view/nephroprotective-potentials-of-methanol-extract-of-dennettiatripetala-pepper-fruit-fresh-leaves-on-male-albino-rats-ndubueze-john-paul-e-7-2. Accessed 26 Dec. 2024.
JOHN-PAUL, EKENE. "Nephroprotective Potentials Of Methanol Extract Of Dennettiatripetala (Pepper Fruit) Fresh Leaves On Male Albino Rats:- Ndubueze, John-paul E.". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 14 Oct. 2024. Web. 26 Dec. 2024. < https://repository.mouau.edu.ng/work/view/nephroprotective-potentials-of-methanol-extract-of-dennettiatripetala-pepper-fruit-fresh-leaves-on-male-albino-rats-ndubueze-john-paul-e-7-2 >.
JOHN-PAUL, EKENE. "Nephroprotective Potentials Of Methanol Extract Of Dennettiatripetala (Pepper Fruit) Fresh Leaves On Male Albino Rats:- Ndubueze, John-paul E." Repository.mouau.edu.ng (2024). Accessed 26 Dec. 2024. https://repository.mouau.edu.ng/work/view/nephroprotective-potentials-of-methanol-extract-of-dennettiatripetala-pepper-fruit-fresh-leaves-on-male-albino-rats-ndubueze-john-paul-e-7-2