Ld50 Evaluation And Effects Of Aqueous Extract Of Pleuroteous Ostriatus Grown On Hcl - Soaked Palm Oil Bunch On Serum Albumin And Total Protein In Wistar Albino Rat
ABSTRACT
This study evaluated the LD50and the effects of aqueous extract of Pleurotous.ostriatus grown on HC1 — soaked palm oil bunch on serum albumin and total protein on wistar albino rats. The mushroom was grown on different concentration of HCI (O.lm to O.5m). After fruiting. they were harvested, dried, milled and persevered for further experiment with respect to the rats, group 1. severed as normal control and was administered only drugs and water ad hibitum while groups two "2" through six "6" received aqueous extract of the mushroom grown on different concentration (group 2 = O.lm HCI grown mushroom, group 3= O.2m. group 4 O.3m, group 5 O.4m, group 6= O.5m). Twenty four (24) male wistar ailbino rats and eighteen (8) mice where used for the study and fed vital growers mesh and water ad hibitum. The rats were further grouped into six (6) groups (n=4) while the mice used for tile LD50experiment using standard method were grouped into two major phases. The experiment lasted for a period of 21days after which they were sacrificed using standard protocul and blood collected for biochemical necessary. The results of the LD50experiment show that the first and second phases of the LD50experiment had no toxicity as no mortality was recorded. The result of total protein showed that the O.2m HC1 and O.3m HCl groups shows significant (p<O.05) increased when compared to the control, while the result for serum albumin showed O.3m HCI to be significantly (p<O.OS) decreased when compared with the control. In conclusion, it could be seen from this work that mushroom grown on POB soaked in O.3m HCI has rio biochemical effect on protein synthesis and function.
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ONUORAH, C (2021). Ld50 Evaluation And Effects Of Aqueous Extract Of Pleuroteous Ostriatus Grown On Hcl - Soaked Palm Oil Bunch On Serum Albumin And Total Protein In Wistar Albino Rat. Repository.mouau.edu.ng: Retrieved Nov 24, 2024, from https://repository.mouau.edu.ng/work/view/ld50-evaluation-and-effects-of-aqueous-extract-of-pleuroteous-ostriatus-grown-on-hcl-soaked-palm-oil-bunch-on-serum-albumin-and-total-protein-in-wistar-albino-rat-7-2
CHUKWUEBUKA, ONUORAH. "Ld50 Evaluation And Effects Of Aqueous Extract Of Pleuroteous Ostriatus Grown On Hcl - Soaked Palm Oil Bunch On Serum Albumin And Total Protein In Wistar Albino Rat" Repository.mouau.edu.ng. Repository.mouau.edu.ng, 24 Jun. 2021, https://repository.mouau.edu.ng/work/view/ld50-evaluation-and-effects-of-aqueous-extract-of-pleuroteous-ostriatus-grown-on-hcl-soaked-palm-oil-bunch-on-serum-albumin-and-total-protein-in-wistar-albino-rat-7-2. Accessed 24 Nov. 2024.
CHUKWUEBUKA, ONUORAH. "Ld50 Evaluation And Effects Of Aqueous Extract Of Pleuroteous Ostriatus Grown On Hcl - Soaked Palm Oil Bunch On Serum Albumin And Total Protein In Wistar Albino Rat". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 24 Jun. 2021. Web. 24 Nov. 2024. < https://repository.mouau.edu.ng/work/view/ld50-evaluation-and-effects-of-aqueous-extract-of-pleuroteous-ostriatus-grown-on-hcl-soaked-palm-oil-bunch-on-serum-albumin-and-total-protein-in-wistar-albino-rat-7-2 >.
CHUKWUEBUKA, ONUORAH. "Ld50 Evaluation And Effects Of Aqueous Extract Of Pleuroteous Ostriatus Grown On Hcl - Soaked Palm Oil Bunch On Serum Albumin And Total Protein In Wistar Albino Rat" Repository.mouau.edu.ng (2021). Accessed 24 Nov. 2024. https://repository.mouau.edu.ng/work/view/ld50-evaluation-and-effects-of-aqueous-extract-of-pleuroteous-ostriatus-grown-on-hcl-soaked-palm-oil-bunch-on-serum-albumin-and-total-protein-in-wistar-albino-rat-7-2