ABSTRACT The incidence of enteropathogenic Escherichia coil among children with or without diarrhoea in Aba Nigeria. Two hundred stool samples were collected from infants and children with diarrhoeal disease under two years of age in Aba, Nigeria were investigated. The samples were collected from five hospitals in Aba. The stool samples were cultured on MacConkey and Blood agar and incubated aerobically at 37°C for 24K Colonies showing typical E. coil growth were tested using various biochemical tests. The E. coii strains were further serotyped using enteropathogernc K coil monovalent antisera. The incidence of EPEC as a causative agent of infantile diarrhea was found to be 19.5 % in the diarrhoeal group and 6% in the control group. The study revealed that the serotype 026k60 B (6) had the highest significant effect (P< 0.05), indicating that it was most prevalent in Aba with rate of 48.7% followed by 0126 K 71 BC (16) and 0111 k58 B (4) with rates of 20.5% and 12.8%. A total of 17.9% of the isolated E. coil were untyped. The most susceptible age group infected by EPEC was 7-13 month followed by 14-20 month age group. Antibiotic susceptibility test showed that the enteropathogenic E. coil isolated was highly resistant to commonly used antibiotic Ampicillin. Septrin and Ampiclox with resistant rates of 89.7%, 7 1.8% and 64.1% respectively. More so Ciprofioxacin, Ceftriaxone and Tarivid showed high degree of sensitivity to the EPEC isolated with rates of 92.1%, 82.1% and 76.9% respectively. All the three EPEC serotypes isolated survived in various weaning foods. Growth profile of the strains showed to be a logarithmic phase of growth during the first 6hours. This study demonstrated that enteropathogenic E. coli is the most common bacteria causing diarrhoea in infants. K coil can survive in infant weaning foods if not consumed after preparation or held for less than 8 h. Ampicillin, Ampiclox and Septrin are quite ineffective in treating these infections