ABSTRACT
Immunodulation refers to a process and a
course of action in which an immune response is altered to a desired level.
Immunomodulation is generally used to describe the pharmacological manipulation
of the state of activity of the immune system. Immunomodulators either make an
increase or decrease in the magnitutude of immune response. The oil bean seed
was purchased, some partwere fermented and the other part unfermented for
further study with respect to the rats. The control received feed and water,
group 1 (unfermented group) received feed, water and a gavage administration of
pyrogallol solution with dose volume of 0.39ml. Group 2(fermented group)
received feed, water and gavage administration of pyrogallol solution with dose
volume of 0.41ml. All administration was done daily for 28days after which the
rats were sacrificed using standard protocols and blood samples collected for
biochemical assays. Ten female wistar albino rats were used for this study and
fed vital growers mash and water daily. The rats were further grouped into
three groups. From the results obtained, it can be observed that in the groups
treated with fermented Pentaclethra macrophylla there were significant (P<
0.05) increases in the value of WBC, Platelets, PCV, GPx, GSH and Secondary
antibody concentration when compared to the normal and it can also be observed
that in the positive control which was treated with only pyrogallol, there were
significant (P< 0.05) decreases in the value of RBC, PCV, CAT, GSH and
Secondary antibody when compared to the normal. There was also observed changes
on administration of either fermented or unfermented due to its medicinal
benefits.
HOPE, O (2024). Immunomodulatory Potential Of Fermented And Unfermented Pentaclethra Macrophylla Seeds In Wistar Albino Rats:- Opara, Hope O. Repository.mouau.edu.ng: Retrieved Nov 10, 2024, from https://repository.mouau.edu.ng/work/view/immunomodulatory-potential-of-fermented-and-unfermented-pentaclethra-macrophylla-seeds-in-wistar-albino-rats-opara-hope-o-7-2
OZIOMA, HOPE. "Immunomodulatory Potential Of Fermented And Unfermented Pentaclethra Macrophylla Seeds In Wistar Albino Rats:- Opara, Hope O" Repository.mouau.edu.ng. Repository.mouau.edu.ng, 10 Oct. 2024, https://repository.mouau.edu.ng/work/view/immunomodulatory-potential-of-fermented-and-unfermented-pentaclethra-macrophylla-seeds-in-wistar-albino-rats-opara-hope-o-7-2. Accessed 10 Nov. 2024.
OZIOMA, HOPE. "Immunomodulatory Potential Of Fermented And Unfermented Pentaclethra Macrophylla Seeds In Wistar Albino Rats:- Opara, Hope O". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 10 Oct. 2024. Web. 10 Nov. 2024. < https://repository.mouau.edu.ng/work/view/immunomodulatory-potential-of-fermented-and-unfermented-pentaclethra-macrophylla-seeds-in-wistar-albino-rats-opara-hope-o-7-2 >.
OZIOMA, HOPE. "Immunomodulatory Potential Of Fermented And Unfermented Pentaclethra Macrophylla Seeds In Wistar Albino Rats:- Opara, Hope O" Repository.mouau.edu.ng (2024). Accessed 10 Nov. 2024. https://repository.mouau.edu.ng/work/view/immunomodulatory-potential-of-fermented-and-unfermented-pentaclethra-macrophylla-seeds-in-wistar-albino-rats-opara-hope-o-7-2