ABSTRACT
In recent times, the
cultivation of Orange Flesh Sweet Potato (OFSP) has advanced its industrial
applications due to its high β-carotene and dry matter content. This study was
aimed at evaluating the hepatoprotective and antihyperlipidaemic effects of
OFSP juice. A total of 85 male Sprague
Dawley rats (80-120g) were used for
this study. Sixty rats were used for the hepatoprotective (preventive and
curative) study. The animals were grouped into five groups; Group 1- Normal
control, Group 2- Untreated, Group 3- Silymarin, Groups 4 – 5 (300 and 600
mg/kg body weight of OFSP, respectively). Twenty-five (25) rats were used for
the antihyperlipideamic study consisting of five groups; Group 1- High fat diet
control (HFDC), Group 2- Low fat diet control (LFDC), Group 3- 200 mg/kg b. w
of OFSP, Group 4- 400 mg/kg b. w. of OFSP, Group 5- 600 mg/kg b. w. of OFSP.
The biochemical analyses were determined using standard biochemical methods. The
results indicated significant (p<0.05) decrease in the total bilirubin (TB)
concentrations of the OFSP-treated preventive (12.02 ± 0.39) and curative (4.35
± 0.21) groups compared to the untreated preventive (20.97 ± 1.27) and curative
(17.22 ± 0.20) groups of the rats. There were also significant (p<0.05)
decrease in the CB, AST, ALT and ALP activities in the OFSP treated groups
relative to the untreated in the preventive and curative models. The haemoglobin
concentration (HB) 9.51 ± 0.26, packed cell volume (PCV) 28.43 ± 0.32, red
blood cell (RBC) 5.44 ± 0.25, total lymphocyte count (TLC) 11.95 ± 0.13 and
platelet count (PLAT) 115.70 ± 0.85 were significantly (p<0.05) increased in
the OFSP treated group when compared to the untreated and silymarin-treated
group. There were no visible histological changes (alterations) in the OFSP-treated
groups compared to the untreated group. For the antihyperlipidaemic study, the
cholesterol concentration was 65.06 ± 10.25 in the high fat diet control, 52.24
± 6.72 in the low fat diet control and 61.22 ± 1.52 for the OFSP treated group
this showed that there was no significant (p<0.05) difference in the OFSP treated
group and HFDC/LFDC. Triglyceride also showed no significant (p<0.05)
difference in the OFSP (89.64±9.06) and the HFDC (105.74±16.52)/LFDC (78.50±1.67)
group while High density lipoprotein (HDL) showed a significant (p<0.05)
increase in the OFSP treated group (29.92±1.85) compared to the HFDC
(15.56±2.10), LDL and VLDL showed a significant (0.05) decrease in the OFSP
treated group compared to the HFDC. It is concluded from this study that OFSP
juice can ameliorate liver damage and may have a mild antihyperlipidaemic potential.
EWA, E (2022). Hepatoprotective And Antihyperlipideamic Effect Of Orange Flesh Sweet Potato Juice (Ipomea Batatas) In Sprague Dawley Rats. Repository.mouau.edu.ng: Retrieved Dec 09, 2024, from https://repository.mouau.edu.ng/work/view/hepatoprotective-and-antihyperlipideamic-effect-of-orange-flesh-sweet-potato-juice-ipomea-batatas-in-sprague-dawley-rats-7-2
EWA, EWA. "Hepatoprotective And Antihyperlipideamic Effect Of Orange Flesh Sweet Potato Juice (Ipomea Batatas) In Sprague Dawley Rats" Repository.mouau.edu.ng. Repository.mouau.edu.ng, 14 Nov. 2022, https://repository.mouau.edu.ng/work/view/hepatoprotective-and-antihyperlipideamic-effect-of-orange-flesh-sweet-potato-juice-ipomea-batatas-in-sprague-dawley-rats-7-2. Accessed 09 Dec. 2024.
EWA, EWA. "Hepatoprotective And Antihyperlipideamic Effect Of Orange Flesh Sweet Potato Juice (Ipomea Batatas) In Sprague Dawley Rats". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 14 Nov. 2022. Web. 09 Dec. 2024. < https://repository.mouau.edu.ng/work/view/hepatoprotective-and-antihyperlipideamic-effect-of-orange-flesh-sweet-potato-juice-ipomea-batatas-in-sprague-dawley-rats-7-2 >.
EWA, EWA. "Hepatoprotective And Antihyperlipideamic Effect Of Orange Flesh Sweet Potato Juice (Ipomea Batatas) In Sprague Dawley Rats" Repository.mouau.edu.ng (2022). Accessed 09 Dec. 2024. https://repository.mouau.edu.ng/work/view/hepatoprotective-and-antihyperlipideamic-effect-of-orange-flesh-sweet-potato-juice-ipomea-batatas-in-sprague-dawley-rats-7-2