Hepatoprotective And Antihyperlipideamic Effect Of Orange Flesh Sweet Potato Juice (Ipomea Batatas) In Sprague Dawley Rats

EWA | 185 pages (32649 words) | Theses
Biochemistry | Co Authors: IBE CHIGOZIE

ABSTRACT

In recent times, the cultivation of Orange Flesh Sweet Potato (OFSP) has advanced its industrial applications due to its high β-carotene and dry matter content. This study was aimed at evaluating the hepatoprotective and antihyperlipidaemic effects of OFSP juice. A total of 85 male Sprague Dawley rats (80-120g)      were used for this study. Sixty rats were used for the hepatoprotective (preventive and curative) study. The animals were grouped into five groups; Group 1- Normal control, Group 2- Untreated, Group 3- Silymarin, Groups 4 – 5 (300 and 600 mg/kg body weight of OFSP, respectively). Twenty-five (25) rats were used for the antihyperlipideamic study consisting of five groups; Group 1- High fat diet control (HFDC), Group 2- Low fat diet control (LFDC), Group 3- 200 mg/kg b. w of OFSP, Group 4- 400 mg/kg b. w. of OFSP, Group 5- 600 mg/kg b. w. of OFSP. The biochemical analyses were determined using standard biochemical methods. The results indicated significant (p<0.05) decrease in the total bilirubin (TB) concentrations of the OFSP-treated preventive (12.02 ± 0.39) and curative (4.35 ± 0.21) groups compared to the untreated preventive (20.97 ± 1.27) and curative (17.22 ± 0.20) groups of the rats. There were also significant (p<0.05) decrease in the CB, AST, ALT and ALP activities in the OFSP treated groups relative to the untreated in the preventive and curative models. The haemoglobin concentration (HB) 9.51 ± 0.26, packed cell volume (PCV) 28.43 ± 0.32, red blood cell (RBC) 5.44 ± 0.25, total lymphocyte count (TLC) 11.95 ± 0.13 and platelet count (PLAT) 115.70 ± 0.85 were significantly (p<0.05) increased in the OFSP treated group when compared to the untreated and silymarin-treated group. There were no visible histological changes (alterations) in the OFSP-treated groups compared to the untreated group. For the antihyperlipidaemic study, the cholesterol concentration was 65.06 ± 10.25 in the high fat diet control, 52.24 ± 6.72 in the low fat diet control and 61.22 ± 1.52 for the OFSP treated group this showed that there was no significant (p<0.05) difference in the OFSP treated group and HFDC/LFDC. Triglyceride also showed no significant (p<0.05) difference in the OFSP (89.64±9.06) and the HFDC (105.74±16.52)/LFDC (78.50±1.67) group while High density lipoprotein (HDL) showed a significant (p<0.05) increase in the OFSP treated group (29.92±1.85) compared to the HFDC (15.56±2.10), LDL and VLDL showed a significant (0.05) decrease in the OFSP treated group compared to the HFDC. It is concluded from this study that OFSP juice can ameliorate liver damage and may have a mild antihyperlipidaemic potential.

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APA

EWA, E (2022). Hepatoprotective And Antihyperlipideamic Effect Of Orange Flesh Sweet Potato Juice (Ipomea Batatas) In Sprague Dawley Rats. Repository.mouau.edu.ng: Retrieved Jan 26, 2023, from https://repository.mouau.edu.ng/work/view/hepatoprotective-and-antihyperlipideamic-effect-of-orange-flesh-sweet-potato-juice-ipomea-batatas-in-sprague-dawley-rats-7-2

MLA 8th

EWA, EWA. "Hepatoprotective And Antihyperlipideamic Effect Of Orange Flesh Sweet Potato Juice (Ipomea Batatas) In Sprague Dawley Rats" Repository.mouau.edu.ng. Repository.mouau.edu.ng, 14 Nov. 2022, https://repository.mouau.edu.ng/work/view/hepatoprotective-and-antihyperlipideamic-effect-of-orange-flesh-sweet-potato-juice-ipomea-batatas-in-sprague-dawley-rats-7-2. Accessed 26 Jan. 2023.

MLA7

EWA, EWA. "Hepatoprotective And Antihyperlipideamic Effect Of Orange Flesh Sweet Potato Juice (Ipomea Batatas) In Sprague Dawley Rats". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 14 Nov. 2022. Web. 26 Jan. 2023. < https://repository.mouau.edu.ng/work/view/hepatoprotective-and-antihyperlipideamic-effect-of-orange-flesh-sweet-potato-juice-ipomea-batatas-in-sprague-dawley-rats-7-2 >.

Chicago

EWA, EWA. "Hepatoprotective And Antihyperlipideamic Effect Of Orange Flesh Sweet Potato Juice (Ipomea Batatas) In Sprague Dawley Rats" Repository.mouau.edu.ng (2022). Accessed 26 Jan. 2023. https://repository.mouau.edu.ng/work/view/hepatoprotective-and-antihyperlipideamic-effect-of-orange-flesh-sweet-potato-juice-ipomea-batatas-in-sprague-dawley-rats-7-2

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