Glutathione Peroxidase Activity in the Serum and Liver Homogenate of Normal and Monosodium Glutamate-Intoxicated Rats Co-Treated with Artemeter And Lumafantrine:- Ezenwafor, Nnaemeka
ABSTRACT
The present study investigated the glutathione
peroxidase activity in the serum and liver homogenate of normal and monosodium
glutamate-intoxicated rats co-treated with artemeter and lumafantrine. 30 male
wistar albino rats weighing 80-140g were randomly sectioned into 6 groups(n=5),
as follows: Normal group: feed and water only; ALC therapeutic dose group:
0.17ml ALC, feed, and water; ALC overdose group: ALC therapeutic dose
multiplied by 5(0.8ml), teed and water; MSG-only group: MSG (8mg/g bodyweight),
feed and water; MSG+ALC therapeutic dose group: ALC therapeutic dose(0.17ml) +
MSG (8mg/g bodyweight), feed and water;MSG+ALC (overdose): ALC (overdose)
(0.85) + MSG (8mg/g bodyweight), feed and water. After 7-days of treatment the
rats were humanely sacrificed and blood samples and liver tissue collected for
glutathione peroxidase assay. Results showed less than normal liver glutathione
peroxidase activity in all treatments in the order: ALC (overdose)
(19.72±1.59)> ALC (therapeutic dose) (17.51±1.56)> MSG+ALC (therapeutic
dose) (15.77±0.55)> MSG+ALC (overdose) (15.56±0.70)> MSG-only rats
(13.32+1.21). Mean serum glutathione peroxidase activity of MSG-only rats
(1.67+0.13) was significantly (P<0.05) lower than Normal (4.60+0.36), ALC
(therapeutic dose) (3.82+0.38), ALC (overdose) (4.62+0.22), MSG+ALC
(therapeutic dose) (3.66+0.37), and MSG+ALC (overdose) (7.50+0.33) groups
respectively. Liver homogenates showed higher Gpx activities than serum. The
study confirmed a possible deleterious effect of MSG and ALC administration on
glutathione peroxidase activity in serum and liver homogenates as evidenced by
reduced Gpx activities especially in liver ofMSG-treated rats, however further
studies will help explain the paradoxical increase in serum Gpx activity seen
in ALC overdose treated rats.
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EZENWAFOR, R (2023). Glutathione Peroxidase Activity in the Serum and Liver Homogenate of Normal and Monosodium Glutamate-Intoxicated Rats Co-Treated with Artemeter And Lumafantrine:- Ezenwafor, Nnaemeka . Repository.mouau.edu.ng: Retrieved Nov 24, 2024, from https://repository.mouau.edu.ng/work/view/glutathione-peroxidase-activity-in-the-serum-and-liver-homogenate-of-normal-and-monosodium-glutamate-intoxicated-rats-co-treated-with-artemeter-and-lumafantrine-ezenwafor-nnaemeka-7-2
RAYMOND, EZENWAFOR. "Glutathione Peroxidase Activity in the Serum and Liver Homogenate of Normal and Monosodium Glutamate-Intoxicated Rats Co-Treated with Artemeter And Lumafantrine:- Ezenwafor, Nnaemeka " Repository.mouau.edu.ng. Repository.mouau.edu.ng, 27 Oct. 2023, https://repository.mouau.edu.ng/work/view/glutathione-peroxidase-activity-in-the-serum-and-liver-homogenate-of-normal-and-monosodium-glutamate-intoxicated-rats-co-treated-with-artemeter-and-lumafantrine-ezenwafor-nnaemeka-7-2. Accessed 24 Nov. 2024.
RAYMOND, EZENWAFOR. "Glutathione Peroxidase Activity in the Serum and Liver Homogenate of Normal and Monosodium Glutamate-Intoxicated Rats Co-Treated with Artemeter And Lumafantrine:- Ezenwafor, Nnaemeka ". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 27 Oct. 2023. Web. 24 Nov. 2024. < https://repository.mouau.edu.ng/work/view/glutathione-peroxidase-activity-in-the-serum-and-liver-homogenate-of-normal-and-monosodium-glutamate-intoxicated-rats-co-treated-with-artemeter-and-lumafantrine-ezenwafor-nnaemeka-7-2 >.
RAYMOND, EZENWAFOR. "Glutathione Peroxidase Activity in the Serum and Liver Homogenate of Normal and Monosodium Glutamate-Intoxicated Rats Co-Treated with Artemeter And Lumafantrine:- Ezenwafor, Nnaemeka " Repository.mouau.edu.ng (2023). Accessed 24 Nov. 2024. https://repository.mouau.edu.ng/work/view/glutathione-peroxidase-activity-in-the-serum-and-liver-homogenate-of-normal-and-monosodium-glutamate-intoxicated-rats-co-treated-with-artemeter-and-lumafantrine-ezenwafor-nnaemeka-7-2