Evaluation On The Effect Of Methanol Extract Of Urtica Dioca Leaves On Liver And Kidney Parameters In Dihydrotesteosterone Estradiol Valarate Induced Benign Prostatic Hyperplasia (Bph) In Male Wistar Rat.
ABSTRACT
The effect of Urtica dioica leaves on kidney and liver functions was investigated in dihydrotestosterone- estradiol valarate induced Benign prostatic hyperplasia in male wistar rats. A total of 20 rats weighing 120-150g were divided according to their body weight into five groups. One group was used as a control group and other group received subcutaneous injection of dihydrotestosterone and estradiol for 28 days. Group II was used as disease control, Group III received Finasteride. Group IV and V was treated with 100mg/kg bw and 200 mg/kg bw of Urtica dioica extract. The result of the result of the phytochemical analysis showed the presence of Alkaloids, Flavonoid, Saponin, Tannins and Phytosterols. The result of the acute toxicity studies showed that the extract was safe at 2759 mg/kg bw of the extract. The result showed that relative heart and kidney weight of the disease control were not significant at P>0.05 significant level. However, the relative prostate weight increased significantly in the disease control when compared with normal group. The level of Prostatic Specific Antigen, Urea, Creatinine and Albumin were significantly (P<0.05) reduced in other experimental group when compared with the disease control. Also, the result showed significant (P<0.05) increase in AST, ALT and ALP in disease control when compared to normal group and experimental groups. The result showed that the extract of U dioica was able to restore the integrity of kidney and the liver thereby offering a nephroprotective and renal protective effect on the two vital organs. Hence, the extract can be pharmacologically useful in management of benign prostatic hyperplasia.
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ANYADI, M (2021). Evaluation On The Effect Of Methanol Extract Of Urtica Dioca Leaves On Liver And Kidney Parameters In Dihydrotesteosterone Estradiol Valarate Induced Benign Prostatic Hyperplasia (Bph) In Male Wistar Rat.. Repository.mouau.edu.ng: Retrieved Nov 23, 2024, from https://repository.mouau.edu.ng/work/view/evaluation-on-the-effect-of-methanol-extract-of-urtica-dioca-leaves-on-liver-and-kidney-parameters-in-dihydrotesteosterone-estradiol-valarate-induced-benign-prostatic-hyperplasia-bph-in-male-wistar-rat-7-2
MARGARET, ANYADI. "Evaluation On The Effect Of Methanol Extract Of Urtica Dioca Leaves On Liver And Kidney Parameters In Dihydrotesteosterone Estradiol Valarate Induced Benign Prostatic Hyperplasia (Bph) In Male Wistar Rat." Repository.mouau.edu.ng. Repository.mouau.edu.ng, 18 Jun. 2021, https://repository.mouau.edu.ng/work/view/evaluation-on-the-effect-of-methanol-extract-of-urtica-dioca-leaves-on-liver-and-kidney-parameters-in-dihydrotesteosterone-estradiol-valarate-induced-benign-prostatic-hyperplasia-bph-in-male-wistar-rat-7-2. Accessed 23 Nov. 2024.
MARGARET, ANYADI. "Evaluation On The Effect Of Methanol Extract Of Urtica Dioca Leaves On Liver And Kidney Parameters In Dihydrotesteosterone Estradiol Valarate Induced Benign Prostatic Hyperplasia (Bph) In Male Wistar Rat.". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 18 Jun. 2021. Web. 23 Nov. 2024. < https://repository.mouau.edu.ng/work/view/evaluation-on-the-effect-of-methanol-extract-of-urtica-dioca-leaves-on-liver-and-kidney-parameters-in-dihydrotesteosterone-estradiol-valarate-induced-benign-prostatic-hyperplasia-bph-in-male-wistar-rat-7-2 >.
MARGARET, ANYADI. "Evaluation On The Effect Of Methanol Extract Of Urtica Dioca Leaves On Liver And Kidney Parameters In Dihydrotesteosterone Estradiol Valarate Induced Benign Prostatic Hyperplasia (Bph) In Male Wistar Rat." Repository.mouau.edu.ng (2021). Accessed 23 Nov. 2024. https://repository.mouau.edu.ng/work/view/evaluation-on-the-effect-of-methanol-extract-of-urtica-dioca-leaves-on-liver-and-kidney-parameters-in-dihydrotesteosterone-estradiol-valarate-induced-benign-prostatic-hyperplasia-bph-in-male-wistar-rat-7-2