ABSTRACT
In vivo evaluation of methanol extract of Cajanus
cajan seeds was carried out using female wistai* albino rats in the laboratory.
Twelve (12) female wistar albino rats were grouped into thi*ee (3) according to
weight range and fed vital growers mash and water ad libitum. Group 1 served as
normal control group and was administered vital growers mash and water ad
libitum. Group 2 served as positive control group and was administered
pyrogallol, water and vital growers mash. Group 3 served as test group and was
administered pyrogallol, Cajanus cajan. extract, water and fed vital growers
mash ad libitum. These experiments took 7 weeks (1 week acclimatization. 1 week
administration of pyrogallol and 4 weeks administration of Cajanus cajan
extract & pyrogallol), after which the animals were sacrificed and the
serum was analyzed for Glutatliione peroxidase (GPx), Glutathione (GSH),
Vitamin E, Malondialdehyde (MDA), Catalase (CAT), Platelets, Haemoglobin (HB),
Red blood cells (RBC), Packed cell volume (PCV), White blood cells (WBC),
Primaiy and Secondary antibody. The results obtained showed a significant
(P< 0.05) increase in GPx activity, GSH activity, catalase activity, WBC count,
HB levels, RBC concentration, PCV content, primary and secondary antibody
concentration of the immune suppressed Cajanus cajan treated group, when
compared with the positive control group. The results also showed a non-
significant increase in the vitamin E concentration in the positive control
group, and a significant (P< 0.05) increase in the MDA concentration and
platelets levels, fbr the positive control group when compared with the immune
suppressed Cajanus cajan treated group. This study confirmed that Cajanus cajan
possess immune- stimulatory effect.
OGBODO, U (2023). Evaluation Of The Immunomodulatory Potential Of Methanol Extract Of Cajanus Cajan Seeds In Wistar Albino Rats. Repository.mouau.edu.ng: Retrieved Dec 09, 2024, from https://repository.mouau.edu.ng/work/view/evaluation-of-the-immunomodulatory-potential-of-methanol-extract-of-cajanus-cajan-seeds-in-wistar-albino-rats-7-2
UZOAMAKA, OGBODO. "Evaluation Of The Immunomodulatory Potential Of Methanol Extract Of Cajanus Cajan Seeds In Wistar Albino Rats" Repository.mouau.edu.ng. Repository.mouau.edu.ng, 10 Aug. 2023, https://repository.mouau.edu.ng/work/view/evaluation-of-the-immunomodulatory-potential-of-methanol-extract-of-cajanus-cajan-seeds-in-wistar-albino-rats-7-2. Accessed 09 Dec. 2024.
UZOAMAKA, OGBODO. "Evaluation Of The Immunomodulatory Potential Of Methanol Extract Of Cajanus Cajan Seeds In Wistar Albino Rats". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 10 Aug. 2023. Web. 09 Dec. 2024. < https://repository.mouau.edu.ng/work/view/evaluation-of-the-immunomodulatory-potential-of-methanol-extract-of-cajanus-cajan-seeds-in-wistar-albino-rats-7-2 >.
UZOAMAKA, OGBODO. "Evaluation Of The Immunomodulatory Potential Of Methanol Extract Of Cajanus Cajan Seeds In Wistar Albino Rats" Repository.mouau.edu.ng (2023). Accessed 09 Dec. 2024. https://repository.mouau.edu.ng/work/view/evaluation-of-the-immunomodulatory-potential-of-methanol-extract-of-cajanus-cajan-seeds-in-wistar-albino-rats-7-2