“Evaluation of The Hepato-Protective Activity of The Combination of Vitamin C And Vitamin E of Paracetamol Induced Toxicity In Wistar Albino Rats:- Adiole Confidence C.
ABSTRACT
Vitamins
E and C are two of the chemical agents that have received wide attention due to
reported Hepatoprotective effects. This could be due to the antioxidant
activities of these two vitamins. Paracetamol as an analgesic can cause
hepatotoxicity at high doses. This study is aimed at determining the efficacy
ofthe combination ofVitamin C and Vitamin E in moping out the free radicals
produced by paracetamol toxicity. Twenty-one male albino rats were used as my
experimental model. The hepatoprotective effect of vitamins C and E against
paracetamol-induced toxicity was assessed in these rats. Vitamin C at
prophylactic dosage; (200mg, 150mg, lOOmg, 50mg, 25mg) and Vitamin E at
prophylactic dosage; (500iu, 400iu, 300iu, 200iu, lOOiu) were separately
administered orally to the test rats (groups 1 to 5) concomitantly with
inducedparacetamol toxicity except group 7, which was the normal control. The
experimental work lasted for seven days; after which the animals were
sacrificed and blood samples were collected from each of them for the necessary
liver function tests. After the tests, it was deduced paracetamol toxicity was
observed to increase significantly (P < 0.05) activities of serum ALT, AST,
and ALP in male albino rats. Oral administration of prophylactic doses of
ascorbic acid and a-tocopherol decreased significantly (P < 0.05) activities
ofthese parameters in male albino rats, compared with the nontreated test rats;
but insignificant increase (P > 0.05), compared with the normal Based on the
study, Co-administration of ascorbic acid and cion paracetamol-induced
hepatotoxicity in wistar albino rats had significant effect in reducing damage
incurred on liver during paracetamol toxicity;
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ADIOLE, C (2024). “Evaluation of The Hepato-Protective Activity of The Combination of Vitamin C And Vitamin E of Paracetamol Induced Toxicity In Wistar Albino Rats:- Adiole Confidence C.. Repository.mouau.edu.ng: Retrieved Jul 27, 2024, from https://repository.mouau.edu.ng/work/view/evaluation-of-the-hepato-protective-activity-of-the-combination-of-vitamin-c-and-vitamin-e-of-paracetamol-induced-toxicity-in-wistar-albino-rats-adiole-confidence-c-7-2
CHIDIEBERE, ADIOLE. "“Evaluation of The Hepato-Protective Activity of The Combination of Vitamin C And Vitamin E of Paracetamol Induced Toxicity In Wistar Albino Rats:- Adiole Confidence C." Repository.mouau.edu.ng. Repository.mouau.edu.ng, 20 Feb. 2024, https://repository.mouau.edu.ng/work/view/evaluation-of-the-hepato-protective-activity-of-the-combination-of-vitamin-c-and-vitamin-e-of-paracetamol-induced-toxicity-in-wistar-albino-rats-adiole-confidence-c-7-2. Accessed 27 Jul. 2024.
CHIDIEBERE, ADIOLE. "“Evaluation of The Hepato-Protective Activity of The Combination of Vitamin C And Vitamin E of Paracetamol Induced Toxicity In Wistar Albino Rats:- Adiole Confidence C.". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 20 Feb. 2024. Web. 27 Jul. 2024. < https://repository.mouau.edu.ng/work/view/evaluation-of-the-hepato-protective-activity-of-the-combination-of-vitamin-c-and-vitamin-e-of-paracetamol-induced-toxicity-in-wistar-albino-rats-adiole-confidence-c-7-2 >.
CHIDIEBERE, ADIOLE. "“Evaluation of The Hepato-Protective Activity of The Combination of Vitamin C And Vitamin E of Paracetamol Induced Toxicity In Wistar Albino Rats:- Adiole Confidence C." Repository.mouau.edu.ng (2024). Accessed 27 Jul. 2024. https://repository.mouau.edu.ng/work/view/evaluation-of-the-hepato-protective-activity-of-the-combination-of-vitamin-c-and-vitamin-e-of-paracetamol-induced-toxicity-in-wistar-albino-rats-adiole-confidence-c-7-2