Evaluation Of Oxytocic Potential Of Methanol Extract Of Sida Acuta On Female Albino Rats.
ABSTRACT
Plants have long been a source of nutrition and therapy to man. The medicinal value of these plants lies in some chemical substances that produce a definite physiological action in the human body. This study evaluated the oxytocic potential of methanol extract of Sida acuta on female albino rats in vitro. Oxytocin was used as a standard drug though it is a biochemically synthesized hormone that act on distant hormone receptor to induce contractions. The methanol extract was prepared using cold maceration method. Matured female non pregnant albino rats were used for this study using their uterine smooth muscle tissue. The extracts 667pgJml, 1334pgIml and 2668jig1rn1 was applied respectively to the organ bath containing the uterine tissue and using a digital physiological recorder, the extract was found to induce contraction of the uterine tissue. The extract produced its optimum frequency at 2668jgIml (57.10%). The extract like oxytocin induce contraction by increasing Ca2influx which activates Ca2dependent cytosolic protein (calmodulin) to form Ca2tcalmodulin complex.
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OBIALOR, I (2021). Evaluation Of Oxytocic Potential Of Methanol Extract Of Sida Acuta On Female Albino Rats.. Repository.mouau.edu.ng: Retrieved Nov 23, 2024, from https://repository.mouau.edu.ng/work/view/evaluation-of-oxytocic-potential-of-methanol-extract-of-sida-acuta-on-female-albino-rats-7-2
IKECHUKWU, OBIALOR. "Evaluation Of Oxytocic Potential Of Methanol Extract Of Sida Acuta On Female Albino Rats." Repository.mouau.edu.ng. Repository.mouau.edu.ng, 16 Jun. 2021, https://repository.mouau.edu.ng/work/view/evaluation-of-oxytocic-potential-of-methanol-extract-of-sida-acuta-on-female-albino-rats-7-2. Accessed 23 Nov. 2024.
IKECHUKWU, OBIALOR. "Evaluation Of Oxytocic Potential Of Methanol Extract Of Sida Acuta On Female Albino Rats.". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 16 Jun. 2021. Web. 23 Nov. 2024. < https://repository.mouau.edu.ng/work/view/evaluation-of-oxytocic-potential-of-methanol-extract-of-sida-acuta-on-female-albino-rats-7-2 >.
IKECHUKWU, OBIALOR. "Evaluation Of Oxytocic Potential Of Methanol Extract Of Sida Acuta On Female Albino Rats." Repository.mouau.edu.ng (2021). Accessed 23 Nov. 2024. https://repository.mouau.edu.ng/work/view/evaluation-of-oxytocic-potential-of-methanol-extract-of-sida-acuta-on-female-albino-rats-7-2