Evaluation Of Antiinflammatory And Analgesic Properties Of Ethanol Leaves Extract Of Newbouldia Laevis In Wistar Albino Rats:- Egesi, Modestus C.
ABSTRACT
This work
studied the analgesic and anti-inflammatory effects of the ethanol leaf extract
of Newbouldia laevis in wistar albino rats. Investigations were carried out on
acetic acid-induced writhing and egg albumen-induced hind paw oedema in rats. A
total oftwenty (20) adult male albino wistar rats weighing 65 - 120g were used
for the study and grouped into 5 groups (n=4). Group I (Standard): The animals
were provided with Vital growers mash feed and water ad libitum. Group II
(Control): They were administered normal saline.Group III through V were
administered the plant extract at 250 mg/kg, 500 mg/kg and 750 mg/kg body
weight, respectively. The results showed that the ethanol extract possessed
significant (p< 0.05) anti-nociceptive activity between 500 and 750 mg/kg
orally and also dose dependent anti-inflammatory activity between 250 and 750
mg/kg in rats. These effects were compared favourably with that expressed by
morphine and indomethacin, respectively (10 mg/kg). From the results obtained,
the extract exhibited highest anti-nociceptive and antiinflammatory activities
at the dosage of 750 mg/kg. These data corroborate with the traditional use of
this plant in the treatment of rheumatic pain and other types ofpain reported
in traditional medicine.
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EGESI, E (2023). Evaluation Of Antiinflammatory And Analgesic Properties Of Ethanol Leaves Extract Of Newbouldia Laevis In Wistar Albino Rats:- Egesi, Modestus C. . Repository.mouau.edu.ng: Retrieved Nov 24, 2024, from https://repository.mouau.edu.ng/work/view/evaluation-of-antiinflammatory-and-analgesic-properties-of-ethanol-leaves-extract-of-newbouldia-laevis-in-wistar-albino-rats-egesi-modestus-c-7-2
EGESI, EGESI. "Evaluation Of Antiinflammatory And Analgesic Properties Of Ethanol Leaves Extract Of Newbouldia Laevis In Wistar Albino Rats:- Egesi, Modestus C. " Repository.mouau.edu.ng. Repository.mouau.edu.ng, 27 Oct. 2023, https://repository.mouau.edu.ng/work/view/evaluation-of-antiinflammatory-and-analgesic-properties-of-ethanol-leaves-extract-of-newbouldia-laevis-in-wistar-albino-rats-egesi-modestus-c-7-2. Accessed 24 Nov. 2024.
EGESI, EGESI. "Evaluation Of Antiinflammatory And Analgesic Properties Of Ethanol Leaves Extract Of Newbouldia Laevis In Wistar Albino Rats:- Egesi, Modestus C. ". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 27 Oct. 2023. Web. 24 Nov. 2024. < https://repository.mouau.edu.ng/work/view/evaluation-of-antiinflammatory-and-analgesic-properties-of-ethanol-leaves-extract-of-newbouldia-laevis-in-wistar-albino-rats-egesi-modestus-c-7-2 >.
EGESI, EGESI. "Evaluation Of Antiinflammatory And Analgesic Properties Of Ethanol Leaves Extract Of Newbouldia Laevis In Wistar Albino Rats:- Egesi, Modestus C. " Repository.mouau.edu.ng (2023). Accessed 24 Nov. 2024. https://repository.mouau.edu.ng/work/view/evaluation-of-antiinflammatory-and-analgesic-properties-of-ethanol-leaves-extract-of-newbouldia-laevis-in-wistar-albino-rats-egesi-modestus-c-7-2