Evaluation Of Anti inflammatory And Analgesic Properties Of Ethanol Leaves Extract Of Newbouldia Laevis In Wistar Albino Rats:- Egesi, Modestus C

EGESI | 48 pages (8449 words) | Projects
Biochemistry | Co Authors: MODESTUS CHIKA

ABSTRACT

This work studied the analgesic and anti-inflammatory effects of the ethanol leaf extract of Newbouldia laevis in wistar albino rats. Investigations were carried out on acetic acid-induced writhing and egg albumen-induced hind paw oedema in rats. A total oftwenty (20) adult male albino wistar rats weighing 65 - 120g were used for the study and grouped into 5 groups (n=4). Group I (Standard): The animals were provided with Vital growers mash feed and water ad libitum. Group II (Control): They were administered normal saline.Group III through V were administered the plant extract at 250 mg/kg, 500 mg/kg and 750 mg/kg body weight, respectively. The results showed that the ethanol extract possessed significant (p< 0.05) anti-nociceptive activity between 500 and 750 mg/kg orally and also dose dependent anti-inflammatory activity between 250 and 750 mg/kg in rats. These effects were compared favourably with that expressed by morphine and indomethacin, respectively (10 mg/kg). From the results obtained, the extract exhibited highest anti-nociceptive and antiinflammatory activities at the dosage of 750 mg/kg. These data corroborate with the traditional use of this plant in the treatment of rheumatic pain and other types ofpain reported in traditional medicine. 

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APA

EGESI, E (2024). Evaluation Of Anti inflammatory And Analgesic Properties Of Ethanol Leaves Extract Of Newbouldia Laevis In Wistar Albino Rats:- Egesi, Modestus C . Repository.mouau.edu.ng: Retrieved Jul 17, 2024, from https://repository.mouau.edu.ng/work/view/evaluation-of-anti-inflammatory-and-analgesic-properties-of-ethanol-leaves-extract-of-newbouldia-laevis-in-wistar-albino-rats-egesi-modestus-c-7-2

MLA 8th

EGESI, EGESI. "Evaluation Of Anti inflammatory And Analgesic Properties Of Ethanol Leaves Extract Of Newbouldia Laevis In Wistar Albino Rats:- Egesi, Modestus C " Repository.mouau.edu.ng. Repository.mouau.edu.ng, 13 Jun. 2024, https://repository.mouau.edu.ng/work/view/evaluation-of-anti-inflammatory-and-analgesic-properties-of-ethanol-leaves-extract-of-newbouldia-laevis-in-wistar-albino-rats-egesi-modestus-c-7-2. Accessed 17 Jul. 2024.

MLA7

EGESI, EGESI. "Evaluation Of Anti inflammatory And Analgesic Properties Of Ethanol Leaves Extract Of Newbouldia Laevis In Wistar Albino Rats:- Egesi, Modestus C ". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 13 Jun. 2024. Web. 17 Jul. 2024. < https://repository.mouau.edu.ng/work/view/evaluation-of-anti-inflammatory-and-analgesic-properties-of-ethanol-leaves-extract-of-newbouldia-laevis-in-wistar-albino-rats-egesi-modestus-c-7-2 >.

Chicago

EGESI, EGESI. "Evaluation Of Anti inflammatory And Analgesic Properties Of Ethanol Leaves Extract Of Newbouldia Laevis In Wistar Albino Rats:- Egesi, Modestus C " Repository.mouau.edu.ng (2024). Accessed 17 Jul. 2024. https://repository.mouau.edu.ng/work/view/evaluation-of-anti-inflammatory-and-analgesic-properties-of-ethanol-leaves-extract-of-newbouldia-laevis-in-wistar-albino-rats-egesi-modestus-c-7-2

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