ABSTRACT
Inflanunation is a complex biological response of
vascular tissue to harmful stimuli such as pathogen, damage cells or irritants.
Attention increasingly has been directed to natural products. These are often
more affordable and available and sometimes are perceived as more effective
than conventional anti- inflammatory drugs. Chronic wounds are a common
complication in patients with diabetes that often lead to amputation. These
non-healing wounds are described as being stuck in a persistent inflammatory
state characterized by accumulation of proinflammatory macrophages, cytokines
and proteases. Some medications approved for management of type 2 diabetes have
demonstrated anti-inflammatory properties independent of their marketed
insulinotropic effects and thus have underappreciated p·otential to promote
wound healing. The available evidence indicates that diabetic medications have
potential to prevent wounds from becoming arrested in the inflammatory stage of
healing and to promote wound healing by down-regulating pro-inflammatory
cytokines, upregulating growth factors, lowering matrix metalloproteinascs,
stimulating angiogenesis, and increasing epithelization. However, no clinical
recommendations currently exist on the potential for specific diabetic
medications to impact healing of chronic wounds. Abelmoschus esculentus is
widely used in ethno medicine in diverse cultures. The anti-inflammatory
activity of okro fruits was carried out using accepted chemical and biochemical
methods. It was carried out at a concentration of 0.10, 0.40, 0.80. and ·1.00
respectively. Inhibition as well as control was observed to be 91.21 ±
1.96/0.10 g/ml, 92.60 ± 1.14/0.40 g/ml, 93.78 ± 0.00 /0.80g/ml, 94.26 ±
0.00/1.00. The results showed elevated level of inhibition. Data was analyzed
statistically using SPSS version 22.0 and significance was accepted at
(P<0.05 ).
MICHAEL, U (2023). Evaluation Of Anti-Inflamatory Activities Of Extracts Of Abelmoscus Esculentus Seeds. Repository.mouau.edu.ng: Retrieved Sep 08, 2024, from https://repository.mouau.edu.ng/work/view/evaluation-of-anti-inflamatory-activities-of-extracts-of-abelmoscus-esculentus-seeds-7-2
UNIVERSITY, MICHAEL. "Evaluation Of Anti-Inflamatory Activities Of Extracts Of Abelmoscus Esculentus Seeds" Repository.mouau.edu.ng. Repository.mouau.edu.ng, 30 Jun. 2023, https://repository.mouau.edu.ng/work/view/evaluation-of-anti-inflamatory-activities-of-extracts-of-abelmoscus-esculentus-seeds-7-2. Accessed 08 Sep. 2024.
UNIVERSITY, MICHAEL. "Evaluation Of Anti-Inflamatory Activities Of Extracts Of Abelmoscus Esculentus Seeds". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 30 Jun. 2023. Web. 08 Sep. 2024. < https://repository.mouau.edu.ng/work/view/evaluation-of-anti-inflamatory-activities-of-extracts-of-abelmoscus-esculentus-seeds-7-2 >.
UNIVERSITY, MICHAEL. "Evaluation Of Anti-Inflamatory Activities Of Extracts Of Abelmoscus Esculentus Seeds" Repository.mouau.edu.ng (2023). Accessed 08 Sep. 2024. https://repository.mouau.edu.ng/work/view/evaluation-of-anti-inflamatory-activities-of-extracts-of-abelmoscus-esculentus-seeds-7-2