ABSTRACT

Inflanunation is a complex biological response of vascular tissue to harmful stimuli such as pathogen, damage cells or irritants. Attention increasingly has been directed to natural products. These are often more affordable and available and sometimes are perceived as more effective than conventional anti- inflammatory drugs. Chronic wounds are a common complication in patients with diabetes that often lead to amputation. These non-healing wounds are described as being stuck in a persistent inflammatory state characterized by accumulation of proinflammatory macrophages, cytokines and proteases. Some medications approved for management of type 2 diabetes have demonstrated anti-inflammatory properties independent of their marketed insulinotropic effects and thus have underappreciated p·otential to promote wound healing. The available evidence indicates that diabetic medications have potential to prevent wounds from becoming arrested in the inflammatory stage of healing and to promote wound healing by down-regulating pro-inflammatory cytokines, upregulating growth factors, lowering matrix metalloproteinascs, stimulating angiogenesis, and increasing epithelization. However, no clinical recommendations currently exist on the potential for specific diabetic medications to impact healing of chronic wounds. Abelmoschus esculentus is widely used in ethno medicine in diverse cultures. The anti-inflammatory activity of okro fruits was carried out using accepted chemical and biochemical methods. It was carried out at a concentration of 0.10, 0.40, 0.80. and ·1.00 respectively. Inhibition as well as control was observed to be 91.21 ± 1.96/0.10 g/ml, 92.60 ± 1.14/0.40 g/ml, 93.78 ± 0.00 /0.80g/ml, 94.26 ± 0.00/1.00. The results showed elevated level of inhibition. Data was analyzed statistically using SPSS version 22.0 and significance was accepted at (P<0.05 ).