Effects Of The Methanol Extract Of The Leaves Of M. Paradisiaca On The Activity Of Superoxide Dismutase (Sod) Of Indomethacin ulcerated Rats:-George Akudo P.
ABSTRACT
The damage induced to cellular constituents by
oxygen-derived free radicals have been shown to play a major role in the origin
and development of a wide range of chronic disorders such as ulcer, cancer,
atherosclerosis among others. Medicinal plants have long played important roles
in the treatment of diseases all over the world. Medicinal plants contain a
number of medicinal properties. One of such plant is M. paradisiaca. The
present study was therefore, designed to investigate the phytochemical
constituents, acute toxicity and lethality and the effect of the methanol
extract of the leaves of M. paradisiaca on the activity of superoxide dismutase
(SOD) of indomethacin-ulcerated rats. The preliminary phytochemical screening
revealed that the extract contained alkaloids, flavonoids, tannins, saponins,
carbohydrates, reducing sugars, proteins, steroids, terpenoids and fats and oil
but resins, glycosides and acidic compounds were not detected. The extract at
the tested doses [100, 200 and 400 mg/kg body weight (b.w)] caused significant
(p < 0.05) and dosedependent increases on the activity of SOD of the rats in
the test groups compared to the values obtained for the rats in the ulcer
untreated group (group 2). The effects of the 400 mg/kg b.w of the extract were
similar to those of the standard anti-ulcer drug, famotidine at the dose of 50
mg/kg b.w. The results indicate that the methanol extract of the leaves of M.
paradisiaca possesses SOD activity-boosting potential in gastric ulcer
condition.
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GEORGE, P (2024). Effects Of The Methanol Extract Of The Leaves Of M. Paradisiaca On The Activity Of Superoxide Dismutase (Sod) Of Indomethacin ulcerated Rats:-George Akudo P. . Repository.mouau.edu.ng: Retrieved Nov 24, 2024, from https://repository.mouau.edu.ng/work/view/effects-of-the-methanol-extract-of-the-leaves-of-m-paradisiaca-on-the-activity-of-superoxide-dismutase-sod-of-indomethacin-ulcerated-rats-george-akudo-p-7-2
PEACE, GEORGE. "Effects Of The Methanol Extract Of The Leaves Of M. Paradisiaca On The Activity Of Superoxide Dismutase (Sod) Of Indomethacin ulcerated Rats:-George Akudo P. " Repository.mouau.edu.ng. Repository.mouau.edu.ng, 29 Feb. 2024, https://repository.mouau.edu.ng/work/view/effects-of-the-methanol-extract-of-the-leaves-of-m-paradisiaca-on-the-activity-of-superoxide-dismutase-sod-of-indomethacin-ulcerated-rats-george-akudo-p-7-2. Accessed 24 Nov. 2024.
PEACE, GEORGE. "Effects Of The Methanol Extract Of The Leaves Of M. Paradisiaca On The Activity Of Superoxide Dismutase (Sod) Of Indomethacin ulcerated Rats:-George Akudo P. ". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 29 Feb. 2024. Web. 24 Nov. 2024. < https://repository.mouau.edu.ng/work/view/effects-of-the-methanol-extract-of-the-leaves-of-m-paradisiaca-on-the-activity-of-superoxide-dismutase-sod-of-indomethacin-ulcerated-rats-george-akudo-p-7-2 >.
PEACE, GEORGE. "Effects Of The Methanol Extract Of The Leaves Of M. Paradisiaca On The Activity Of Superoxide Dismutase (Sod) Of Indomethacin ulcerated Rats:-George Akudo P. " Repository.mouau.edu.ng (2024). Accessed 24 Nov. 2024. https://repository.mouau.edu.ng/work/view/effects-of-the-methanol-extract-of-the-leaves-of-m-paradisiaca-on-the-activity-of-superoxide-dismutase-sod-of-indomethacin-ulcerated-rats-george-akudo-p-7-2