Effects Of The Ethanol Extract Of The Leaves Of Man Gifera Indica On The Concentration Of Total Proteins And Specific Activity Of Catalase Of Aspirin-Ulcerated Rats
ABSTRACT
The use of
certain plants in traditional medicine started as far back as ancient times and
such plants are still widely in use today such as the application of the leaves
of M indica in the cure of gastric ulcer. The objectives of this work were to
examine the phytochemical constituents, acute toxicity and lethality and
effects of the ethanol extract of the leaves of M indica on the concentration
of total proteins and specific activity of catalase of aspirin-ulcerated rats.
The preliminary phytochemical screening revealed that the plant extract
contained alkaloids, flavonoids, tannins, saponins, carbohydrates, glycosides,
proteins, steroids, terpenoids and fats and oil but resins, reducing sugars and
acidic compounds were not detected. The extract was found to be safe even at a
dose as high as 5000 mg/kg body weight (b.w). The extract at the tested doses
(100, 200 and 400 mg/kg b.w) caused significant (p < 0.05) and
dose-dependent increases in the total protein concentration and specific
activity of catalase of the rats in the test groups compared to the values
obtained for the rats in the ulcer-untreated groups. The effects of the 400
mg/kg b.w of the extract were similar to those of the standard anti-ulcer drug,
ranitidine at the dose of 150 mg/kg b.w. The results indicate that the ethanol
extract of the leaves of M indica protects against gastric ulcer in parts, by
raising the concentration of total protein and specific activity of catalase
and therefore, justifies the use of the leaves of M indica in treating gastric
ulcer in traditional medicine
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EZEIKPE, P (2021). Effects Of The Ethanol Extract Of The Leaves Of Man Gifera Indica On The Concentration Of Total Proteins And Specific Activity Of Catalase Of Aspirin-Ulcerated Rats . Repository.mouau.edu.ng: Retrieved Nov 24, 2024, from https://repository.mouau.edu.ng/work/view/effects-of-the-ethanol-extract-of-the-leaves-of-man-gifera-indica-on-the-concentration-of-total-proteins-and-specific-activity-of-catalase-of-aspirin-ulcerated-rats-7-2
PEACE, EZEIKPE. "Effects Of The Ethanol Extract Of The Leaves Of Man Gifera Indica On The Concentration Of Total Proteins And Specific Activity Of Catalase Of Aspirin-Ulcerated Rats " Repository.mouau.edu.ng. Repository.mouau.edu.ng, 29 Jun. 2021, https://repository.mouau.edu.ng/work/view/effects-of-the-ethanol-extract-of-the-leaves-of-man-gifera-indica-on-the-concentration-of-total-proteins-and-specific-activity-of-catalase-of-aspirin-ulcerated-rats-7-2. Accessed 24 Nov. 2024.
PEACE, EZEIKPE. "Effects Of The Ethanol Extract Of The Leaves Of Man Gifera Indica On The Concentration Of Total Proteins And Specific Activity Of Catalase Of Aspirin-Ulcerated Rats ". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 29 Jun. 2021. Web. 24 Nov. 2024. < https://repository.mouau.edu.ng/work/view/effects-of-the-ethanol-extract-of-the-leaves-of-man-gifera-indica-on-the-concentration-of-total-proteins-and-specific-activity-of-catalase-of-aspirin-ulcerated-rats-7-2 >.
PEACE, EZEIKPE. "Effects Of The Ethanol Extract Of The Leaves Of Man Gifera Indica On The Concentration Of Total Proteins And Specific Activity Of Catalase Of Aspirin-Ulcerated Rats " Repository.mouau.edu.ng (2021). Accessed 24 Nov. 2024. https://repository.mouau.edu.ng/work/view/effects-of-the-ethanol-extract-of-the-leaves-of-man-gifera-indica-on-the-concentration-of-total-proteins-and-specific-activity-of-catalase-of-aspirin-ulcerated-rats-7-2