Effects of the Ethanol Extract of the Leaves of M. indica on the Concentration of Total Proteins and Specific Activity of Catalase of Aspirin-ulcerated Rats:- Ezeikpe iheaorochi P.
ABSTRACT
The
use of certain plants in traditional medicine started as far back as ancient
times and such plants are still widely in use today such as the application
ofthe leaves of M. indica in the cure of gastric ulcer. The objectives of this
work were to examine the phytochemical constituents, acute toxicity and
lethality and effects of the ethanol extract of the leaves of M. indica on the
concentration of total proteins and specific activity of catalase of
aspirin-ulcerated rats. The preliminary phytochemical screening revealed that
the plant extract contained alkaloids, flavonoids, tannins, saponins,
carbohydrates, glycosides, proteins, steroids, terpenoids and fats and oil but
resins, reducing sugars and acidic compounds were not detected. The extract was
found to be safe even at a dose as high as 5000 mg/kg body weight (b.w). The
extract at the tested doses (100, 200 and 400 mg/kg b.w) caused significant (p
< 0.05) and dose-dependent increases in the total protein concentration and
specific activity of catalase of the rats in the test groups compared to the
values obtained for the rats in the ulcer-untreated groups. The effects of the
400 mg/kg b.w of the extract were similar to those ofthe standard anti-ulcer
drug, ranitidine at the dose of 150 mg/kg b.w. The results indicate that the
ethanol extract of the leaves of M. indica protects against gastric ulcer in
parts, by raising the concentration of total protein and specific activity of
catalase and therefore, justifies the use ofthe leaves ofM. indica in treating
gastric ulcer in traditional medicine.
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EZEIKPE, P (2024). Effects of the Ethanol Extract of the Leaves of M. indica on the Concentration of Total Proteins and Specific Activity of Catalase of Aspirin-ulcerated Rats:- Ezeikpe iheaorochi P.. Repository.mouau.edu.ng: Retrieved Nov 24, 2024, from https://repository.mouau.edu.ng/work/view/effects-of-the-ethanol-extract-of-the-leaves-of-m-indica-on-the-concentration-of-total-proteins-and-specific-activity-of-catalase-of-aspirin-ulcerated-rats-ezeikpe-iheaorochi-p-7-2
PEACE, EZEIKPE. "Effects of the Ethanol Extract of the Leaves of M. indica on the Concentration of Total Proteins and Specific Activity of Catalase of Aspirin-ulcerated Rats:- Ezeikpe iheaorochi P." Repository.mouau.edu.ng. Repository.mouau.edu.ng, 01 Mar. 2024, https://repository.mouau.edu.ng/work/view/effects-of-the-ethanol-extract-of-the-leaves-of-m-indica-on-the-concentration-of-total-proteins-and-specific-activity-of-catalase-of-aspirin-ulcerated-rats-ezeikpe-iheaorochi-p-7-2. Accessed 24 Nov. 2024.
PEACE, EZEIKPE. "Effects of the Ethanol Extract of the Leaves of M. indica on the Concentration of Total Proteins and Specific Activity of Catalase of Aspirin-ulcerated Rats:- Ezeikpe iheaorochi P.". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 01 Mar. 2024. Web. 24 Nov. 2024. < https://repository.mouau.edu.ng/work/view/effects-of-the-ethanol-extract-of-the-leaves-of-m-indica-on-the-concentration-of-total-proteins-and-specific-activity-of-catalase-of-aspirin-ulcerated-rats-ezeikpe-iheaorochi-p-7-2 >.
PEACE, EZEIKPE. "Effects of the Ethanol Extract of the Leaves of M. indica on the Concentration of Total Proteins and Specific Activity of Catalase of Aspirin-ulcerated Rats:- Ezeikpe iheaorochi P." Repository.mouau.edu.ng (2024). Accessed 24 Nov. 2024. https://repository.mouau.edu.ng/work/view/effects-of-the-ethanol-extract-of-the-leaves-of-m-indica-on-the-concentration-of-total-proteins-and-specific-activity-of-catalase-of-aspirin-ulcerated-rats-ezeikpe-iheaorochi-p-7-2