Effects Of The Ethanol Extract Of The Leaves Of Annona Muricata On Gastric Juice Volume And Gastric Juice Ph Of Aspirin-Ulcerated Rats:- Ejerenwa, Celestina N.
ABSTRACT
Plants have
been the bases for medicinal treatments through much of human history and such
traditional medicine is still widely in use today such as the leaves ofA.
muricata. The objectives of this work were to examine the phytochemical
constituents, acute toxicity and effects of the ethanol extract of the leaves
of A. muricata on gastric juice volume and gastric juice pH of
aspirin-ulcerated rats. The preliminary phytochemical screening revealed that
the plant leaves contained alkaloids, flavonoids, tannins, saponins,
carbohydrates, glycosides, proteins, steroids, terpenoids and fats and oil but
resins, reducing sugars and acidic compounds were not detected. The extract at
the tested doses [100, 200 and 400 mg/kg body weight (b.w)] caused significant
(p < 0.05) and dose-dependent decreases in the gastric juice volumes ofthe
rats in the test groups compared to the values obtained for the rats in the
control group. Significant (p < 0.05) and doserelated increases in gastric juice
pH ofthe rats in the test groups compared to that ofthe rats in the control
group was also brought about by the extract. The effects ofthe 400 mg/kg b.w
ofthe extract were similar to those of the standard anti-ulcer drug, rantidine
at the dose of 150 mg/kg b.w. The results validate the traditional application
ofthe leaves ofA. muricata in the treatment ofgastric ulcer
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CELESTINA, N (2023). Effects Of The Ethanol Extract Of The Leaves Of Annona Muricata On Gastric Juice Volume And Gastric Juice Ph Of Aspirin-Ulcerated Rats:- Ejerenwa, Celestina N.. Repository.mouau.edu.ng: Retrieved Nov 24, 2024, from https://repository.mouau.edu.ng/work/view/effects-of-the-ethanol-extract-of-the-leaves-of-annona-muricata-on-gastric-juice-volume-and-gastric-juice-ph-of-aspirin-ulcerated-rats-ejerenwa-celestina-n-7-2
NKEIRU, CELESTINA. "Effects Of The Ethanol Extract Of The Leaves Of Annona Muricata On Gastric Juice Volume And Gastric Juice Ph Of Aspirin-Ulcerated Rats:- Ejerenwa, Celestina N." Repository.mouau.edu.ng. Repository.mouau.edu.ng, 27 Oct. 2023, https://repository.mouau.edu.ng/work/view/effects-of-the-ethanol-extract-of-the-leaves-of-annona-muricata-on-gastric-juice-volume-and-gastric-juice-ph-of-aspirin-ulcerated-rats-ejerenwa-celestina-n-7-2. Accessed 24 Nov. 2024.
NKEIRU, CELESTINA. "Effects Of The Ethanol Extract Of The Leaves Of Annona Muricata On Gastric Juice Volume And Gastric Juice Ph Of Aspirin-Ulcerated Rats:- Ejerenwa, Celestina N.". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 27 Oct. 2023. Web. 24 Nov. 2024. < https://repository.mouau.edu.ng/work/view/effects-of-the-ethanol-extract-of-the-leaves-of-annona-muricata-on-gastric-juice-volume-and-gastric-juice-ph-of-aspirin-ulcerated-rats-ejerenwa-celestina-n-7-2 >.
NKEIRU, CELESTINA. "Effects Of The Ethanol Extract Of The Leaves Of Annona Muricata On Gastric Juice Volume And Gastric Juice Ph Of Aspirin-Ulcerated Rats:- Ejerenwa, Celestina N." Repository.mouau.edu.ng (2023). Accessed 24 Nov. 2024. https://repository.mouau.edu.ng/work/view/effects-of-the-ethanol-extract-of-the-leaves-of-annona-muricata-on-gastric-juice-volume-and-gastric-juice-ph-of-aspirin-ulcerated-rats-ejerenwa-celestina-n-7-2