Effects of hydro-ethanolic extract of amaranthus hybridus leaves on some haematological profile of thioacetamide intoxicated rats.
ABSTRACT
The study was carried out to
evaluate the effect of hydro-ethanolic extract of Amaranthus hybridus leaves on
some hematological profile of thioacetamide intoxicated rats (wistar).
Thirty-six animals of male gender were used and divided into six groups, each
group consisting of six animals. The normal control received normal feed and
water, the positive control received the thioacetamide induced water and
silymarin (conventional drug), negative control received only thioacetamide,
the test groups were treated with I 00mg/kg, 200mg/kg, 400mg/kg body weight of
Amaranthus hybridus leaves extract respectively. The administration of the
thioacetamide, drug and Amaranths hybridus leaves extract were orally at single
doses per day for nine weeks. The result of the test groups significantly (p
< 0.05) increased the hematological levels of PCV, HB, RBC, and WBC when
compared to the Negative control groups after nine weeks of Amaranthus hybridus
administration to each rat. The results suggest that thioacetamide induces
hepatotoxicity, while Amaranthus hybridus leaves extract appreciably increases
the levels of hematological parameters in the blood.
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EBEH, C (2023). Effects of hydro-ethanolic extract of amaranthus hybridus leaves on some haematological profile of thioacetamide intoxicated rats.. Repository.mouau.edu.ng: Retrieved Nov 25, 2024, from https://repository.mouau.edu.ng/work/view/effects-of-hydro-ethanolic-extract-of-amaranthus-hybridus-leaves-on-some-haematological-profile-of-thioacetamide-intoxicated-rats-7-2
CHUKWUEMEKA, EBEH. "Effects of hydro-ethanolic extract of amaranthus hybridus leaves on some haematological profile of thioacetamide intoxicated rats." Repository.mouau.edu.ng. Repository.mouau.edu.ng, 04 May. 2023, https://repository.mouau.edu.ng/work/view/effects-of-hydro-ethanolic-extract-of-amaranthus-hybridus-leaves-on-some-haematological-profile-of-thioacetamide-intoxicated-rats-7-2. Accessed 25 Nov. 2024.
CHUKWUEMEKA, EBEH. "Effects of hydro-ethanolic extract of amaranthus hybridus leaves on some haematological profile of thioacetamide intoxicated rats.". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 04 May. 2023. Web. 25 Nov. 2024. < https://repository.mouau.edu.ng/work/view/effects-of-hydro-ethanolic-extract-of-amaranthus-hybridus-leaves-on-some-haematological-profile-of-thioacetamide-intoxicated-rats-7-2 >.
CHUKWUEMEKA, EBEH. "Effects of hydro-ethanolic extract of amaranthus hybridus leaves on some haematological profile of thioacetamide intoxicated rats." Repository.mouau.edu.ng (2023). Accessed 25 Nov. 2024. https://repository.mouau.edu.ng/work/view/effects-of-hydro-ethanolic-extract-of-amaranthus-hybridus-leaves-on-some-haematological-profile-of-thioacetamide-intoxicated-rats-7-2