Effects Of Hydro-Ethanolic Extract Of Amaranthus Hybridus Leaves On Some Antioxidant Enzymes In Thioacetamide Intoxicated Rats
ABSTRACT
The study was carried out to evaluate the effect of hydro-alcoholic extract of
Amaranthus hybridus leaves on antioxidant enzymes of thioacetamide
intoxicated rats. Thirty-six rats used for this study were randomly distributed
into six groups. The normal control received normal feed and water, the positive
control received the thioacetamide induced water and silymarin (conventional
drug), negative control received only thioacetamide, the test groups were
treated with 100mg/kg, 200mg/kg, 400mg/kg of Amaranthus hybridus leaves
extract respectively. The administration of the thioacetamide, drug and
Amaranthus hybridus leaves extract were orally at single doses per day for nine
weeks. Result showed that the test groups significantly (p < 0.05) increased the
levels of SOD, CAT, and GPx activities when compared to the negative control.
The results suggest that thioacetamide actually induced hepatotoxicity. While
Amaranthus hybridus leaves extract appreciably increased the levels of
antioxidants in hepatic tissues.
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GODSON, N (2021). Effects Of Hydro-Ethanolic Extract Of Amaranthus Hybridus Leaves On Some Antioxidant Enzymes In Thioacetamide Intoxicated Rats. Repository.mouau.edu.ng: Retrieved Nov 23, 2024, from https://repository.mouau.edu.ng/work/view/effects-of-hydro-ethanolic-extract-of-amaranthus-hybridus-leaves-on-some-antioxidant-enzymes-in-thioacetamide-intoxicated-rats-7-2
NGOZI, GODSON. "Effects Of Hydro-Ethanolic Extract Of Amaranthus Hybridus Leaves On Some Antioxidant Enzymes In Thioacetamide Intoxicated Rats" Repository.mouau.edu.ng. Repository.mouau.edu.ng, 10 Jun. 2021, https://repository.mouau.edu.ng/work/view/effects-of-hydro-ethanolic-extract-of-amaranthus-hybridus-leaves-on-some-antioxidant-enzymes-in-thioacetamide-intoxicated-rats-7-2. Accessed 23 Nov. 2024.
NGOZI, GODSON. "Effects Of Hydro-Ethanolic Extract Of Amaranthus Hybridus Leaves On Some Antioxidant Enzymes In Thioacetamide Intoxicated Rats". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 10 Jun. 2021. Web. 23 Nov. 2024. < https://repository.mouau.edu.ng/work/view/effects-of-hydro-ethanolic-extract-of-amaranthus-hybridus-leaves-on-some-antioxidant-enzymes-in-thioacetamide-intoxicated-rats-7-2 >.
NGOZI, GODSON. "Effects Of Hydro-Ethanolic Extract Of Amaranthus Hybridus Leaves On Some Antioxidant Enzymes In Thioacetamide Intoxicated Rats" Repository.mouau.edu.ng (2021). Accessed 23 Nov. 2024. https://repository.mouau.edu.ng/work/view/effects-of-hydro-ethanolic-extract-of-amaranthus-hybridus-leaves-on-some-antioxidant-enzymes-in-thioacetamide-intoxicated-rats-7-2