“Effect ofthe Methanol Extract of the Leaves of P.guajava on lipid peroxidation of indomethacin-ulcerated rat:- Oko, Rachel O.
ABSTRACT
Plants have been the basis for
medical treatments through much of human history and such traditional medicine
is still widely in use today such as the leaves of P. guajava. The objectives
of this work were to examine the phytochemical constituents, acute toxicity and
lethality and effect of the methanol extract of the leaves of P. guajava on MDA
concentration of Indomethacin-ulcerated rats. The preliminary phytochemical screening
revealed that the extract contained alkaloids, flavonoids, reducing sugars,
tannins, saponins, carbohydrates, proteins, steroids, terpenoids and fats and
oil but resins, glycosides and acidic compounds were not detected. The extract
at the tested doses (100, 200 and 400 mg/kg b.w) caused significant (p <
0.05) and dose-dependent decreases in the MDA concentrations of the rats in the
test groups when compared to the value obtained for the rats in the control
group. The effect of the 400 mg/kg b.w of the extract was similar to that of
the standard anti-ulcer drug, famotidine at the dose of 50 mg/kg b.w. The
results indicate that the methanol extract ofthe leaves ofP. guajava contains
some pharmacological active principles which may help support the use ofthe
leaves of the plants in traditional medicine for the treatments ofgastric
ulcer.
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-- (2023). “Effect ofthe Methanol Extract of the Leaves of P.guajava on lipid peroxidation of indomethacin-ulcerated rat:- Oko, Rachel O.. Repository.mouau.edu.ng: Retrieved Nov 24, 2024, from https://repository.mouau.edu.ng/work/view/effect-ofthe-methanol-extract-of-the-leaves-of-pguajava-on-lipid-peroxidation-of-indomethacin-ulcerated-rat-oko-rachel-o-7-2
--. "“Effect ofthe Methanol Extract of the Leaves of P.guajava on lipid peroxidation of indomethacin-ulcerated rat:- Oko, Rachel O." Repository.mouau.edu.ng. Repository.mouau.edu.ng, 11 Dec. 2023, https://repository.mouau.edu.ng/work/view/effect-ofthe-methanol-extract-of-the-leaves-of-pguajava-on-lipid-peroxidation-of-indomethacin-ulcerated-rat-oko-rachel-o-7-2. Accessed 24 Nov. 2024.
--. "“Effect ofthe Methanol Extract of the Leaves of P.guajava on lipid peroxidation of indomethacin-ulcerated rat:- Oko, Rachel O.". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 11 Dec. 2023. Web. 24 Nov. 2024. < https://repository.mouau.edu.ng/work/view/effect-ofthe-methanol-extract-of-the-leaves-of-pguajava-on-lipid-peroxidation-of-indomethacin-ulcerated-rat-oko-rachel-o-7-2 >.
--. "“Effect ofthe Methanol Extract of the Leaves of P.guajava on lipid peroxidation of indomethacin-ulcerated rat:- Oko, Rachel O." Repository.mouau.edu.ng (2023). Accessed 24 Nov. 2024. https://repository.mouau.edu.ng/work/view/effect-ofthe-methanol-extract-of-the-leaves-of-pguajava-on-lipid-peroxidation-of-indomethacin-ulcerated-rat-oko-rachel-o-7-2