Effect ofmethanol extract of Curcuma longa on Prostate Specific Antigen level and antioxidant parameters of dihydrotesterone-estradiol valarate induced benign prostate hyperplasia (BPH) on male wister albino rat:- Ndukaku Kennedy C.

KENNEDY CHUKWUEBUKA | 64 pages (13742 words) | Projects
Biochemistry | Co Authors: NDUKAKU

ABSTRACT

The effect ofthe administration of methanol extract of Curcumin longa on Prostate specific antigen level, relative organ weight and antioxidant parameters was studied in dihydrotestosterone — estradiol valarate induced benign prostatic hyperplasia (BPH) in male Albino Rats. Phytochemical and acute toxicity study was conducted on the Curcuma longa using standard methods. Twenty rats were divided into five experimental groups of 4 rats each; Group 1- normal control, Group 2- disease control (BPH-group), Group 3- standard drugs control (finasteride-group), Group 4 and 5 (100 and 200 mg/kg of Curcuma longa extract respectively). The normal was not induced with BPH but was given olive oil administered orally (everyday) and subcutaneously (alternative days) for 28 days. The disease control group was induced BPH hormones in an alternative days and oral administration of olive oil lor 28 days. The standard control group (induced BPH) was given finasteride 5mg/70kg administered orally every day. The lOOmg/kg and 200mg/kg of methanol extract of Curcuma longa was given to BPH induced rats orally every day respectively. Results of the phytochemical studies showed high content of flavonoid (4.030 ± 0.014mg/100g) followed by alkaloid and tannin (2.405±0.007 and 2.225 ± 0.021mg/100g respectively). Terpene showed the lowest concentration (0.405 ± 0.007mg/100g). The acute toxicity tests showed that the methanol extract of Curcuma longa is not toxic up to 4500mg/kg. The result also showed that prostate specific antigen (PSA) which is a maker of BPH decreased significantly (P < 0.05) in groups treated with different doses of Curcuma longa extract. Superoxide dismutase and glutathione peroxidase activity, was observed to be significantly (P < 0.05) decreased in disease control group rats compared to the treated groups while a significant (P < 0.05) increase in Malondialdehyde level was observed in the disease control group animals compared to normal control and treated groups. This study reveals important phytochemical constituent which shows that Curcuma longa may have pharmacological efficacy in preventing or suppressing the development ofBPH and useful in its treatment and management. 

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APA

KENNEDY, C (2024). Effect ofmethanol extract of Curcuma longa on Prostate Specific Antigen level and antioxidant parameters of dihydrotesterone-estradiol valarate induced benign prostate hyperplasia (BPH) on male wister albino rat:- Ndukaku Kennedy C. . Repository.mouau.edu.ng: Retrieved May 20, 2024, from https://repository.mouau.edu.ng/work/view/effect-ofmethanol-extract-of-curcuma-longa-on-prostate-specific-antigen-level-and-antioxidant-parameters-of-dihydrotesterone-estradiol-valarate-induced-benign-prostate-hyperplasia-bph-on-male-wister-albino-rat-ndukaku-kennedy-c-7-2

MLA 8th

CHUKWUEBUKA, KENNEDY. "Effect ofmethanol extract of Curcuma longa on Prostate Specific Antigen level and antioxidant parameters of dihydrotesterone-estradiol valarate induced benign prostate hyperplasia (BPH) on male wister albino rat:- Ndukaku Kennedy C. " Repository.mouau.edu.ng. Repository.mouau.edu.ng, 13 Mar. 2024, https://repository.mouau.edu.ng/work/view/effect-ofmethanol-extract-of-curcuma-longa-on-prostate-specific-antigen-level-and-antioxidant-parameters-of-dihydrotesterone-estradiol-valarate-induced-benign-prostate-hyperplasia-bph-on-male-wister-albino-rat-ndukaku-kennedy-c-7-2. Accessed 20 May. 2024.

MLA7

CHUKWUEBUKA, KENNEDY. "Effect ofmethanol extract of Curcuma longa on Prostate Specific Antigen level and antioxidant parameters of dihydrotesterone-estradiol valarate induced benign prostate hyperplasia (BPH) on male wister albino rat:- Ndukaku Kennedy C. ". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 13 Mar. 2024. Web. 20 May. 2024. < https://repository.mouau.edu.ng/work/view/effect-ofmethanol-extract-of-curcuma-longa-on-prostate-specific-antigen-level-and-antioxidant-parameters-of-dihydrotesterone-estradiol-valarate-induced-benign-prostate-hyperplasia-bph-on-male-wister-albino-rat-ndukaku-kennedy-c-7-2 >.

Chicago

CHUKWUEBUKA, KENNEDY. "Effect ofmethanol extract of Curcuma longa on Prostate Specific Antigen level and antioxidant parameters of dihydrotesterone-estradiol valarate induced benign prostate hyperplasia (BPH) on male wister albino rat:- Ndukaku Kennedy C. " Repository.mouau.edu.ng (2024). Accessed 20 May. 2024. https://repository.mouau.edu.ng/work/view/effect-ofmethanol-extract-of-curcuma-longa-on-prostate-specific-antigen-level-and-antioxidant-parameters-of-dihydrotesterone-estradiol-valarate-induced-benign-prostate-hyperplasia-bph-on-male-wister-albino-rat-ndukaku-kennedy-c-7-2

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