Effect Of The Methanol Extract Of The Leaves Of Psidium Guajava (Guava) On Packed Cell Volume (Pcv) Of Indomethacin- Ulcerated Rats
ABSTRACT
Plants have been used medicinally worldwide through much of human history to cure certain ailments such as gastric ulcer. An example of such plants used in the treatment of gastric ulcers is P. guajava. The objectives of this work were to determine the phytochemical constituents, acute toxicity and lethality and the graded doses of the effect of the methanol extract of the leaves of P. guajava on Packed Cell Volume (PCV) of indomethacin-ulcerated rats. The preliminary phytochemical screening revealed that the extract contained alkaloids, flavonoids, tannins, saponins, carbohydrates, reducing sugars, proteins, steroids, terpenoids and fats and oil. Resins, glycosides and acidic compounds were not detected in the extract. The extract at the tested doses [100, 200 and 400 mg/body weight (b.w)] caused significant (p < 0.05) and dose-dependent increases in the packed cell volume of the rats in the test groups compared to that of the rats in the control group. The effect of the 400 mg/kg b.w of the extract was similar to that of the standard anti-ulcer drug, farnotidine at the dose of 50 mg/kg b.w. The result indicates that the methanol extract of the leaves of P. guajava contains some pharmacological active principles which may help in boosting the PCV in ulcer condition.
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UZOKA, C (2021). Effect Of The Methanol Extract Of The Leaves Of Psidium Guajava (Guava) On Packed Cell Volume (Pcv) Of Indomethacin- Ulcerated Rats. Repository.mouau.edu.ng: Retrieved Nov 24, 2024, from https://repository.mouau.edu.ng/work/view/effect-of-the-methanol-extract-of-the-leaves-of-psidium-guajava-guava-on-packed-cell-volume-pcv-of-indomethacin-ulcerated-rats-7-2
CHIAZOKAM, UZOKA. "Effect Of The Methanol Extract Of The Leaves Of Psidium Guajava (Guava) On Packed Cell Volume (Pcv) Of Indomethacin- Ulcerated Rats" Repository.mouau.edu.ng. Repository.mouau.edu.ng, 22 Jun. 2021, https://repository.mouau.edu.ng/work/view/effect-of-the-methanol-extract-of-the-leaves-of-psidium-guajava-guava-on-packed-cell-volume-pcv-of-indomethacin-ulcerated-rats-7-2. Accessed 24 Nov. 2024.
CHIAZOKAM, UZOKA. "Effect Of The Methanol Extract Of The Leaves Of Psidium Guajava (Guava) On Packed Cell Volume (Pcv) Of Indomethacin- Ulcerated Rats". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 22 Jun. 2021. Web. 24 Nov. 2024. < https://repository.mouau.edu.ng/work/view/effect-of-the-methanol-extract-of-the-leaves-of-psidium-guajava-guava-on-packed-cell-volume-pcv-of-indomethacin-ulcerated-rats-7-2 >.
CHIAZOKAM, UZOKA. "Effect Of The Methanol Extract Of The Leaves Of Psidium Guajava (Guava) On Packed Cell Volume (Pcv) Of Indomethacin- Ulcerated Rats" Repository.mouau.edu.ng (2021). Accessed 24 Nov. 2024. https://repository.mouau.edu.ng/work/view/effect-of-the-methanol-extract-of-the-leaves-of-psidium-guajava-guava-on-packed-cell-volume-pcv-of-indomethacin-ulcerated-rats-7-2