Effect Of The Methanol Extract Of The Leaves Of P. Guajava On The Red Blood Cell (Rbc) Count Of IndomethaCin-Ulcerated Rats:- Kalu, Chidinma
ABSTRACT
Plants have been the basis for medical treatments
through much of human history and such traditional medicine is still widely in
use today such as the leaves of P. guajava. The objectives of this work were to
examine the phytochemical constituents, acute toxicity and lethality and
effects of the methanol extract of the leaves of P. guajava on Red blood cell
(RBC) count of indomethacin- ulcerated rats. The preliminary phytochernical
screening revealed that the plant leaves contained alkaloids, flavonoids,
tannins, saponins, carbohydrates, glycosides, proteins, steroids, terpenoids
and fats and oil but resins, reducing sugars and acidic compounds were not
detected. The extract at the tested doses [ 100, 200 and 400 mg/kg body weight
(b.w)] caused significant (p < 0.05) and dosedependent decreases red blood
cell counts of the rats in the test groups compared to the values obtained for
the rats in the control group. Significant (p <0.05) and dose-related
increases in red blood cell count of the rats in the test groups compared to
that of the rats in the control group was also brought about by the extract.
The effects of the 400 mg/kg b.w of the extract were similar to those of the
standard anti-ulcer drug, fonnatidine at the dose of 100 mg/kg b.w. The results
indicate that the methanol extract of the leaves of P. guava contains some
phannacological active principles which may help in the modulation of defensive
factors through an improvement of the red blood cell (RBC) count in a
dosedependent manner.
0.0
KALU, C (2024). Effect Of The Methanol Extract Of The Leaves Of P. Guajava On The Red Blood Cell (Rbc) Count Of IndomethaCin-Ulcerated Rats:- Kalu, Chidinma. Repository.mouau.edu.ng: Retrieved Nov 24, 2024, from https://repository.mouau.edu.ng/work/view/effect-of-the-methanol-extract-of-the-leaves-of-p-guajava-on-the-red-blood-cell-rbc-count-of-indomethacin-ulcerated-rats-kalu-chidinma-7-2
CHIDINMA, KALU. "Effect Of The Methanol Extract Of The Leaves Of P. Guajava On The Red Blood Cell (Rbc) Count Of IndomethaCin-Ulcerated Rats:- Kalu, Chidinma" Repository.mouau.edu.ng. Repository.mouau.edu.ng, 26 Feb. 2024, https://repository.mouau.edu.ng/work/view/effect-of-the-methanol-extract-of-the-leaves-of-p-guajava-on-the-red-blood-cell-rbc-count-of-indomethacin-ulcerated-rats-kalu-chidinma-7-2. Accessed 24 Nov. 2024.
CHIDINMA, KALU. "Effect Of The Methanol Extract Of The Leaves Of P. Guajava On The Red Blood Cell (Rbc) Count Of IndomethaCin-Ulcerated Rats:- Kalu, Chidinma". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 26 Feb. 2024. Web. 24 Nov. 2024. < https://repository.mouau.edu.ng/work/view/effect-of-the-methanol-extract-of-the-leaves-of-p-guajava-on-the-red-blood-cell-rbc-count-of-indomethacin-ulcerated-rats-kalu-chidinma-7-2 >.
CHIDINMA, KALU. "Effect Of The Methanol Extract Of The Leaves Of P. Guajava On The Red Blood Cell (Rbc) Count Of IndomethaCin-Ulcerated Rats:- Kalu, Chidinma" Repository.mouau.edu.ng (2024). Accessed 24 Nov. 2024. https://repository.mouau.edu.ng/work/view/effect-of-the-methanol-extract-of-the-leaves-of-p-guajava-on-the-red-blood-cell-rbc-count-of-indomethacin-ulcerated-rats-kalu-chidinma-7-2