Effect Of The Methanol Extract Of The-Leaves Of P. Guajava On Lipid Peroxidation Of Indomethacin-Ulcerated Rats:- Oko, Rachel O.
ABSTRACT
Plants have
been the basis for medical treatments through much of human history and such
traditional medicine is still widely in use today such as the leaves of P.
guajava. The objectives of this work were to examine the phytochemical
constituents, acute toxicity and lethality and effect of the methanol extract
of the leaves of P. guajava on MDA concentration of Indomethacin-ulcerated
rats. The preliminary phytochemical screening revealed that the extract
contained alkaloids, flavonoids, reducing sugars, tannins, saponins,
carbohydrates, proteins, steroids, terpenoids and fats and oil but resins,
glycosides and acidic compounds were not detected. The extract at the tested
doses (100, 200 and 400 mg/kg b.w) caused significant (p < 0.05)· and
dose-dependent decreases in the MDA concentrations of the rats in the test
groups . when compared to the value obtained for the rats in the control group.
The effect of the 400 mg/kg b. w of the extract was similar to that of the
standard anti-ulcer drug, famotidine at the dose of 50 mg/kg b.w.' The results
indicate that the methanol extract of the leaves of P. guajava contains some
pharmacological active principles which may help support the use of the leaves
of the plants in traditional medicine for the treatments of gastric ulcer.
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OKO, O (2023). Effect Of The Methanol Extract Of The-Leaves Of P. Guajava On Lipid Peroxidation Of Indomethacin-Ulcerated Rats:- Oko, Rachel O.. Repository.mouau.edu.ng: Retrieved Nov 24, 2024, from https://repository.mouau.edu.ng/work/view/effect-of-the-methanol-extract-of-the-leaves-of-p-guajava-on-lipid-peroxidation-of-indomethacin-ulcerated-rats-oko-rachel-o-7-2
OKO, OKO. "Effect Of The Methanol Extract Of The-Leaves Of P. Guajava On Lipid Peroxidation Of Indomethacin-Ulcerated Rats:- Oko, Rachel O." Repository.mouau.edu.ng. Repository.mouau.edu.ng, 13 Nov. 2023, https://repository.mouau.edu.ng/work/view/effect-of-the-methanol-extract-of-the-leaves-of-p-guajava-on-lipid-peroxidation-of-indomethacin-ulcerated-rats-oko-rachel-o-7-2. Accessed 24 Nov. 2024.
OKO, OKO. "Effect Of The Methanol Extract Of The-Leaves Of P. Guajava On Lipid Peroxidation Of Indomethacin-Ulcerated Rats:- Oko, Rachel O.". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 13 Nov. 2023. Web. 24 Nov. 2024. < https://repository.mouau.edu.ng/work/view/effect-of-the-methanol-extract-of-the-leaves-of-p-guajava-on-lipid-peroxidation-of-indomethacin-ulcerated-rats-oko-rachel-o-7-2 >.
OKO, OKO. "Effect Of The Methanol Extract Of The-Leaves Of P. Guajava On Lipid Peroxidation Of Indomethacin-Ulcerated Rats:- Oko, Rachel O." Repository.mouau.edu.ng (2023). Accessed 24 Nov. 2024. https://repository.mouau.edu.ng/work/view/effect-of-the-methanol-extract-of-the-leaves-of-p-guajava-on-lipid-peroxidation-of-indomethacin-ulcerated-rats-oko-rachel-o-7-2