Effect Of The Methanol Extract Of The Leaves Of Musaparadisiaca On Lipid Peroxidation Of Indomethacin-Ulcerated Rats
ABSTRACT
The use of plants and plant products for medicinal treatments predates written
human history and such practice is still widely adopted today such as the use of the
leaves of M paradisiaca in the treatment of gastric ulcer. The objectives of this
work were therefore, to examine the phytochemical constituents, acute toxicity and
lethality and effect of the methanol extract of the leaves of M paradisiaca on the
concentration of malondialdehyde (MDA) of indomethacin-ulcerated rats. The
preliminary phytochemical screening revealed that the extract contained alkaloids,
flavonoids, tannins, saponins, carbohydrates, reducing sugars, proteins, steroids,
terpenoids and fats and oils. Resins, glycosides and acidic compounds were not
detected. The extract was found to be safe even at a dose as high as 5000 mg/kg
body weight (b.w). The extract at the tested doses (100, 200 and 400 mg/kg b.w)
caused significant (p < 0.05) and dose-dependent decreases in the concentration of
MDA of the rats in the test groups compared to the value obtained for the rats in
the control group. The effect of the 400 mg/kg b.w of the extract was similar to that
of the standard anti-ulcer drug, famotidine at the dose of 50 mg/kg b.w. The results
indicate that the methanol extract of the leaves of M paradisiaca contains some
pharmacological active principle which may reduce the concentration of MDA in
ulcerated rats.
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NDUAGUIBE, O (2021). Effect Of The Methanol Extract Of The Leaves Of Musaparadisiaca On Lipid Peroxidation Of Indomethacin-Ulcerated Rats. Repository.mouau.edu.ng: Retrieved Nov 23, 2024, from https://repository.mouau.edu.ng/work/view/effect-of-the-methanol-extract-of-the-leaves-of-musaparadisiaca-on-lipid-peroxidation-of-indomethacin-ulcerated-rats-7-2
OBIANUJU, NDUAGUIBE. "Effect Of The Methanol Extract Of The Leaves Of Musaparadisiaca On Lipid Peroxidation Of Indomethacin-Ulcerated Rats" Repository.mouau.edu.ng. Repository.mouau.edu.ng, 10 Jun. 2021, https://repository.mouau.edu.ng/work/view/effect-of-the-methanol-extract-of-the-leaves-of-musaparadisiaca-on-lipid-peroxidation-of-indomethacin-ulcerated-rats-7-2. Accessed 23 Nov. 2024.
OBIANUJU, NDUAGUIBE. "Effect Of The Methanol Extract Of The Leaves Of Musaparadisiaca On Lipid Peroxidation Of Indomethacin-Ulcerated Rats". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 10 Jun. 2021. Web. 23 Nov. 2024. < https://repository.mouau.edu.ng/work/view/effect-of-the-methanol-extract-of-the-leaves-of-musaparadisiaca-on-lipid-peroxidation-of-indomethacin-ulcerated-rats-7-2 >.
OBIANUJU, NDUAGUIBE. "Effect Of The Methanol Extract Of The Leaves Of Musaparadisiaca On Lipid Peroxidation Of Indomethacin-Ulcerated Rats" Repository.mouau.edu.ng (2021). Accessed 23 Nov. 2024. https://repository.mouau.edu.ng/work/view/effect-of-the-methanol-extract-of-the-leaves-of-musaparadisiaca-on-lipid-peroxidation-of-indomethacin-ulcerated-rats-7-2