Effect of the methanol extract of the leaves of M. paradisiaca on gastric juice volume and gastric juice pH of indomethacin-ulcerated rats:- Nwaeze, Temple A.
ABSTRACT
Plants have been the basis for medicinal
treatments through much of human history and such traditional medicine is still
widely in use today such as the leaves of M. paradisiaca . The objectives of
this work were to examine the phytochemical constituents. acute toxicity and
lethality and effects of the methanol extract of the leaves of M. paradisiaca
on gastric juice volume and gastric juice pH of indomethacin-ulcerated rats.
The preliminary phytochemical screening revealed that the plant leaves
contained alkaloids, flavonoids, tannins, saponins, carbohydrates, glycosides,
proteins, steroids, terpenoids and fats and oil but resins, reducing sugars and
acidic compounds were not detected. The extract at the tested doses [ l 00, 200
and 400 mg/kg body weight (b.w)] caused significant (p <0.05) and dose-dependent
decreases in the gastric juice volumes of the rats in the test groups compared
to the value obtained for the rats in the control group. Significant (p
<0.05) and dose-related increases in gastric juice pH of the rats in the
test groups compared to that of the rats in the control group was also brought
about by the extract. The effects of the 400 mg/kg b.w of the extract were
similar to those of the standard antiulcer drug, famotidine at the dose of 50
mg/kg b.w. The results indicate that the methanol extract of the leaves of M.
paradisiaca contains some pharmacological active principles which may help in
the modulation of defensive factors through an improvement of gastric cy
toprotection and acid reduction in a dose-dependent manner.
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NWAEZE, A (2023). Effect of the methanol extract of the leaves of M. paradisiaca on gastric juice volume and gastric juice pH of indomethacin-ulcerated rats:- Nwaeze, Temple A. . Repository.mouau.edu.ng: Retrieved Nov 24, 2024, from https://repository.mouau.edu.ng/work/view/effect-of-the-methanol-extract-of-the-leaves-of-m-paradisiaca-on-gastric-juice-volume-and-gastric-juice-ph-of-indomethacin-ulcerated-rats-nwaeze-temple-a-7-2
AKACHI, NWAEZE. "Effect of the methanol extract of the leaves of M. paradisiaca on gastric juice volume and gastric juice pH of indomethacin-ulcerated rats:- Nwaeze, Temple A. " Repository.mouau.edu.ng. Repository.mouau.edu.ng, 24 Oct. 2023, https://repository.mouau.edu.ng/work/view/effect-of-the-methanol-extract-of-the-leaves-of-m-paradisiaca-on-gastric-juice-volume-and-gastric-juice-ph-of-indomethacin-ulcerated-rats-nwaeze-temple-a-7-2. Accessed 24 Nov. 2024.
AKACHI, NWAEZE. "Effect of the methanol extract of the leaves of M. paradisiaca on gastric juice volume and gastric juice pH of indomethacin-ulcerated rats:- Nwaeze, Temple A. ". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 24 Oct. 2023. Web. 24 Nov. 2024. < https://repository.mouau.edu.ng/work/view/effect-of-the-methanol-extract-of-the-leaves-of-m-paradisiaca-on-gastric-juice-volume-and-gastric-juice-ph-of-indomethacin-ulcerated-rats-nwaeze-temple-a-7-2 >.
AKACHI, NWAEZE. "Effect of the methanol extract of the leaves of M. paradisiaca on gastric juice volume and gastric juice pH of indomethacin-ulcerated rats:- Nwaeze, Temple A. " Repository.mouau.edu.ng (2023). Accessed 24 Nov. 2024. https://repository.mouau.edu.ng/work/view/effect-of-the-methanol-extract-of-the-leaves-of-m-paradisiaca-on-gastric-juice-volume-and-gastric-juice-ph-of-indomethacin-ulcerated-rats-nwaeze-temple-a-7-2