Effect of the ethanol extract of the leaves ofA. muricata on the Concentration of Glutathione (GSH) of aspirin-ulcerated rats:- Umebuali Chinyere P.
ABSTRACT
Plants
have been the basis for medical treatments through much of human history and
such traditional medicine is still widely in use today such as the leaves of A.
muricata. The objectives of this work were to examine the phytochemical
constituents, acute toxicity and lethality and effect ofthe ethanol extract
ofthe leaves ofA. muricata on the concentration of glutathione (GSH) in
aspirin-ulcerated rats. The preliminary phytochemical screening revealed that
the plant leaves contained alkaloids, flavonoids, tannins saponins,
carbohydrates, glycosides, proteins, steroids, terpenoids and fats and oil.
Resins, reducing sugars and acidic compounds were not detected in the extract.
The extract at the administered doses [100. 200 and 400 mg/kg body weight
(b.w)] caused significant (p < 0.05) and dosedependent increases in the GSH
concentrations ofthe rats in the test groups compared to the value obtained for
the rats in the control group. The effect ofthe 400 mg/kg b.w ofthe extract was
similar to that of the standard anti-ulcer drug, ranitidine at the dose of 150
mg/kg b.w. The results indicate that the ethanol extract of the leaves of A.
muricata contains some pharmacological active principles which may cause
improvement in the GSH concentration of an ulcerated rat.
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UMEBUALI, P (2024). Effect of the ethanol extract of the leaves ofA. muricata on the Concentration of Glutathione (GSH) of aspirin-ulcerated rats:- Umebuali Chinyere P.. Repository.mouau.edu.ng: Retrieved May 07, 2024, from https://repository.mouau.edu.ng/work/view/effect-of-the-ethanol-extract-of-the-leaves-ofa-muricata-on-the-concentration-of-glutathione-gsh-of-aspirin-ulcerated-rats-umebuali-chinyere-p-7-2
PATIENCE, UMEBUALI. "Effect of the ethanol extract of the leaves ofA. muricata on the Concentration of Glutathione (GSH) of aspirin-ulcerated rats:- Umebuali Chinyere P." Repository.mouau.edu.ng. Repository.mouau.edu.ng, 06 Mar. 2024, https://repository.mouau.edu.ng/work/view/effect-of-the-ethanol-extract-of-the-leaves-ofa-muricata-on-the-concentration-of-glutathione-gsh-of-aspirin-ulcerated-rats-umebuali-chinyere-p-7-2. Accessed 07 May. 2024.
PATIENCE, UMEBUALI. "Effect of the ethanol extract of the leaves ofA. muricata on the Concentration of Glutathione (GSH) of aspirin-ulcerated rats:- Umebuali Chinyere P.". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 06 Mar. 2024. Web. 07 May. 2024. < https://repository.mouau.edu.ng/work/view/effect-of-the-ethanol-extract-of-the-leaves-ofa-muricata-on-the-concentration-of-glutathione-gsh-of-aspirin-ulcerated-rats-umebuali-chinyere-p-7-2 >.
PATIENCE, UMEBUALI. "Effect of the ethanol extract of the leaves ofA. muricata on the Concentration of Glutathione (GSH) of aspirin-ulcerated rats:- Umebuali Chinyere P." Repository.mouau.edu.ng (2024). Accessed 07 May. 2024. https://repository.mouau.edu.ng/work/view/effect-of-the-ethanol-extract-of-the-leaves-ofa-muricata-on-the-concentration-of-glutathione-gsh-of-aspirin-ulcerated-rats-umebuali-chinyere-p-7-2