Effect Of The Ethanol Extract Of The Leaves Of annona Muricata On The Concentration Of Glutathione (GSH) Of Aspirin-Ulcerated Rats
ABSTRACT
Plants have been the basis for medical treatments through much of human history and such traditional medicine is still widely in use today such as the leaves of A. muricata. The objectives of this work were to examine the phytochemical constituents, acute toxicity and lethality and effect of the ethanol extract of the leaves of A. muricata on the concentration of glutathione (GSH) in aspirin-ulcerated rats. The preliminary phytochemical screening revealed that the plant leaves contained alkaloids, flavonoids, tannins saponins, carbohydrates, glycosides, proteins, steroids, terpenoids and fats and oil. Resins, reducing sugars and acidic compounds were not detected in the extract. The extract at the administeredoses [100, 200 and 400 mg/kg body weight (b.w)] caused significant (p < 0.05) and dose- dependent increases in the OSH concentrations of the rats in the test groups compared to the value obtained for the rats in the control group. The effect of the 400 mg/kg b.w of the extract
was similar to that of the standard anti-ulcer drug, ranitidine at the dose of 1 50 mg/kg b.w. The results indicate that the ethanol extract of the leaves of A. n2uricata contains some pharmacological active principles which may cause improvement in the GSH concentration of an ulcerated rat.
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UMEBUALI, P (2021). Effect Of The Ethanol Extract Of The Leaves Of annona Muricata On The Concentration Of Glutathione (GSH) Of Aspirin-Ulcerated Rats. Repository.mouau.edu.ng: Retrieved Nov 23, 2024, from https://repository.mouau.edu.ng/work/view/effect-of-the-ethanol-extract-of-the-leaves-of-annona-muricata-on-the-concentration-of-glutathione-gsh-of-aspirin-ulcerated-rats-7-2
PATIENCE, UMEBUALI. "Effect Of The Ethanol Extract Of The Leaves Of annona Muricata On The Concentration Of Glutathione (GSH) Of Aspirin-Ulcerated Rats" Repository.mouau.edu.ng. Repository.mouau.edu.ng, 16 Jun. 2021, https://repository.mouau.edu.ng/work/view/effect-of-the-ethanol-extract-of-the-leaves-of-annona-muricata-on-the-concentration-of-glutathione-gsh-of-aspirin-ulcerated-rats-7-2. Accessed 23 Nov. 2024.
PATIENCE, UMEBUALI. "Effect Of The Ethanol Extract Of The Leaves Of annona Muricata On The Concentration Of Glutathione (GSH) Of Aspirin-Ulcerated Rats". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 16 Jun. 2021. Web. 23 Nov. 2024. < https://repository.mouau.edu.ng/work/view/effect-of-the-ethanol-extract-of-the-leaves-of-annona-muricata-on-the-concentration-of-glutathione-gsh-of-aspirin-ulcerated-rats-7-2 >.
PATIENCE, UMEBUALI. "Effect Of The Ethanol Extract Of The Leaves Of annona Muricata On The Concentration Of Glutathione (GSH) Of Aspirin-Ulcerated Rats" Repository.mouau.edu.ng (2021). Accessed 23 Nov. 2024. https://repository.mouau.edu.ng/work/view/effect-of-the-ethanol-extract-of-the-leaves-of-annona-muricata-on-the-concentration-of-glutathione-gsh-of-aspirin-ulcerated-rats-7-2