Effect Of Oral Administration Of Ethanolic Extract Of Vernonial Amygdalina.Del Leaves On Some Proteins And Enzymes Associated With Pancreatic Function In Weanling Rabbits.
ABSTRACT
The effect of oral
administration of ethanolic extract of vernonia arnygdalina.del on the exocrine
functions of the pancreas was investigated. Administration of extract at doses
of 500mgmg/kg body weight and 100mg/kg body weight produced weight loss of 4.85
±,.3.55g and 6.025 * 6.32g respectively while the control gained 19.56 ±
16.44g. Serum amylase activity was elevated at a high dose of the extract
(392.62 ± 35.22u/1) but remained unaffected at the low dose (105 + 28.12u/1).
Serum chloride was elevated at the high dose (137.0 ± 19.80Meq/I) and the low
dose(124.23 + 8.8lMeq/L) compared to control (101 + 3.3Meq/L) Mean relative
pancreatic weight decreased from 0.00214 ± 0.000352 in the control to 0.00187 +
0.000394 in the high dose group but was unaffected in the low dose group. Total
fecal Output increased from 330.6 in the control to 517.6g and 547.lg in the
low and high dose groups respectively. Activity of fecal trypsin was not
detected in the groups administered the extract but was detected in the
control. Microscopic examination revealed the presence of fat globules and
fatty acid crystals in the stools of the groups administered the extract. These
indicate that the plant extract at high doses affect pancreatic function.
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NNABUCHI, C (2021). Effect Of Oral Administration Of Ethanolic Extract Of Vernonial Amygdalina.Del Leaves On Some Proteins And Enzymes Associated With Pancreatic Function In Weanling Rabbits.. Repository.mouau.edu.ng: Retrieved Nov 23, 2024, from https://repository.mouau.edu.ng/work/view/effect-of-oral-administration-of-ethanolic-extract-of-vernonial-amygdalinadel-leaves-on-some-proteins-and-enzymes-associated-with-pancreatic-function-in-weanling-rabbits-7-2
CHRISTINE, NNABUCHI. "Effect Of Oral Administration Of Ethanolic Extract Of Vernonial Amygdalina.Del Leaves On Some Proteins And Enzymes Associated With Pancreatic Function In Weanling Rabbits." Repository.mouau.edu.ng. Repository.mouau.edu.ng, 30 Jun. 2021, https://repository.mouau.edu.ng/work/view/effect-of-oral-administration-of-ethanolic-extract-of-vernonial-amygdalinadel-leaves-on-some-proteins-and-enzymes-associated-with-pancreatic-function-in-weanling-rabbits-7-2. Accessed 23 Nov. 2024.
CHRISTINE, NNABUCHI. "Effect Of Oral Administration Of Ethanolic Extract Of Vernonial Amygdalina.Del Leaves On Some Proteins And Enzymes Associated With Pancreatic Function In Weanling Rabbits.". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 30 Jun. 2021. Web. 23 Nov. 2024. < https://repository.mouau.edu.ng/work/view/effect-of-oral-administration-of-ethanolic-extract-of-vernonial-amygdalinadel-leaves-on-some-proteins-and-enzymes-associated-with-pancreatic-function-in-weanling-rabbits-7-2 >.
CHRISTINE, NNABUCHI. "Effect Of Oral Administration Of Ethanolic Extract Of Vernonial Amygdalina.Del Leaves On Some Proteins And Enzymes Associated With Pancreatic Function In Weanling Rabbits." Repository.mouau.edu.ng (2021). Accessed 23 Nov. 2024. https://repository.mouau.edu.ng/work/view/effect-of-oral-administration-of-ethanolic-extract-of-vernonial-amygdalinadel-leaves-on-some-proteins-and-enzymes-associated-with-pancreatic-function-in-weanling-rabbits-7-2