ABSTRACT
This
study determined the effect of n-hexane extract of Emilia sonchifolia leaves on
some.haematological parameters in rats exposed to sodium arsenite (NaAsO2).
Twenty eight (28) male albino rats were divided into four (4) groups of seven
(7) rats per group. Group I: control rats received feed and water only,Group
II: received 250mg/kg b. wt ofEmilia sonchifolia extract orally, Group III:
receive 2.5 mg/kg b.wt of sodium arsenite intraperitoneally,while Group IV:
received 2.5mg/kg b.wt ofsodium arsenite+250/ngZtg b.wt ofEmilia sonchifolia.
Treatment were given daily for 14days. At the end of the 14‘" day, rats in
each groups were sacrificed and blood samples were collected by ocular puncture
for the determination of haematological parameters which include: Hb, PCV, RBC,
WBC, Platelets, MCV, MCH, MCHC, ,Neutrophils etc. The result showed a
nonsignificant (p>0.05) different in platelets when compared to group 1 and
significant (p<0.05) increase when compared to group3,this as a result of
thrombocytopenia after sodium arsenite intoxification. In RBC level it shows a
significant (p<0.05) decrease when compared to group 1, and a significant
(p<0.05) decrease when compared to group 3. The one treated with Emillia
sonchifolia shows a significant (p<0.05) increase in WBC level when compared
to group 1, whereas significant (p<0.05) decrease when compared to group 3
because of the toxic action of the sodium arsenite. HB level was high in group
1, also in group 3 this is an indication that extract could increase erythropoesis
in animals. PCV level was high in the extract and sodium arsenite treated group
when compared to group 3, Neutrophil level showed low when compared to group 1
but high when compared to group 3 which specifies that Emillia sonchifolia
improves phagocytic activity. Lymphocytes level was observed high when group
compared to group 1 but slight low when compared to group 3 because the extract
decreases the effector cells of the immune system. MCV, MCH and MCHC levels
showed high when compared to group 1 also, showed high when compared to group
3. The result therefore suggests that the n-hexane extract of Emilia
sonchifolia leaves possessed hematinic, immune-boosting effects as well as
antioxidant activity in Wistar albino rats as observed by the significant
elevation of the haematological parameters. This could be as a result of
presences of phytochemicals like flavanoids,terpenes in the Emillia sonchifolia
plants extracts.
OKEKE, O (2024). Effect Of N-Hexane Extract Of Emilia Sonchifolia On Some Haematological Parameters In Rats Exposed To Sodium Arsenite:- Okeke Lilian O. Repository.mouau.edu.ng: Retrieved Oct 10, 2024, from https://repository.mouau.edu.ng/work/view/effect-of-n-hexane-extract-of-emilia-sonchifolia-on-some-haematological-parameters-in-rats-exposed-to-sodium-arsenite-okeke-lilian-o-7-2
OKPO, OKEKE. "Effect Of N-Hexane Extract Of Emilia Sonchifolia On Some Haematological Parameters In Rats Exposed To Sodium Arsenite:- Okeke Lilian O" Repository.mouau.edu.ng. Repository.mouau.edu.ng, 04 Sep. 2024, https://repository.mouau.edu.ng/work/view/effect-of-n-hexane-extract-of-emilia-sonchifolia-on-some-haematological-parameters-in-rats-exposed-to-sodium-arsenite-okeke-lilian-o-7-2. Accessed 10 Oct. 2024.
OKPO, OKEKE. "Effect Of N-Hexane Extract Of Emilia Sonchifolia On Some Haematological Parameters In Rats Exposed To Sodium Arsenite:- Okeke Lilian O". Repository.mouau.edu.ng, Repository.mouau.edu.ng, 04 Sep. 2024. Web. 10 Oct. 2024. < https://repository.mouau.edu.ng/work/view/effect-of-n-hexane-extract-of-emilia-sonchifolia-on-some-haematological-parameters-in-rats-exposed-to-sodium-arsenite-okeke-lilian-o-7-2 >.
OKPO, OKEKE. "Effect Of N-Hexane Extract Of Emilia Sonchifolia On Some Haematological Parameters In Rats Exposed To Sodium Arsenite:- Okeke Lilian O" Repository.mouau.edu.ng (2024). Accessed 10 Oct. 2024. https://repository.mouau.edu.ng/work/view/effect-of-n-hexane-extract-of-emilia-sonchifolia-on-some-haematological-parameters-in-rats-exposed-to-sodium-arsenite-okeke-lilian-o-7-2